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ON JANUARY 29th, speaking to a packed room at CSAM's first Annual Legislative Day, Senator Wesley Chesbro announced that earlier that morning he had introduced SB101, SENATOR WESLEY CHESBRO a new Substance AT CSAM LEGISLATIVE Abuse Health DAY ON JANUARY 29. Insurance Parity Bill and that he would lead the fight for this legislation in 2003. Senator Chesbro's bill is an exact copy of SB599 introduced in the last year and drafted by Senator Chesbro with input from CSAM. SB599 passed the State Senate and Assembly Health Committee but failed to make it out of the Assembly after governor Davis indicated that he would not sign the legislation. See article CSAM Public Policy Committee Breaks New Ground. ; CSAM's Legislative Day was a huge success. Over 80 people participated in a half day educational workshop that featured presentations by lobbyist Jim Gonzalez of Jim Gonzalez and Associates ; and Bryce Docerty of Continued on page five.
5. Is the patient a good candidate for primary antithyroid drug therapy, or is she unlikely to achieve a remission, making radioiodine a better choice? Many retrospective studies have been conducted to try to address the question of whether there are baseline predictors that might help to identify those patients who are most likely to have a remission after a course of antithyroid drugs 1 ; . To summarize the studies briefly, almost all of them show the highest remission rates in patients with relatively small goiters in whom thyroid function tests are only slightly deranged e.g. Refs. 48 50 ; . Factors such as age, sex, the presence of ophthalmopathy, smoking history, and prior history of relapse have not consistently been shown to predict success or failure with sufficient sensitivity or specificity to be useful in individual patient management. The absence of circulating anti-TSH receptor antibodies at baseline has been shown to be predictive of remission 51 ; , but negative titers are seen mainly in patients with the mildest disease in any case. In accord with this observation, one retrospective 48 ; and one prospective study 52 ; demonstrated that patients with higher baseline anti-TSH receptor antibody titers are more likely to relapse. In the European Multicentre Trial cited above, baseline factors were examined to see whether any of them might predict the likelihood of subsequent remission 35 ; . A total of 313 patients were followed for a mean of 4.3 yr with a mean relapse rate of 58% in the group receiving 10 mg d vs. 57% in the group receiving 40 mg d ; . There were no differences at baseline between those who eventually relapsed and those who had a sustained remission in age, goiter size, eye findings, thyroid function tests, or history of prior relapse. Anti-TSH receptor antibody measurements were not reported, nor did the authors perform subgroup analysis retrospectively to see whether patients with the mildest disease or smallest goiters might have had higher remission rates compared with those with the most severe disease or largest goiters. In summary, the large body of retrospective data are likely correct: severe disease and large goiter are poor prognostic features for achieving a remission, but this has been difficult to demonstrate in prospective studies.
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12.3 months 95% CI, 7.817.8 ; , and the 1-year survival rate was 52% 95% CI, 3272% ; . KaplanMeier curves for overall survival and TTP are shown in Fig. 1. TOXICITY All 25 patients were assessable for toxicity. The highest grades of hematological and non-hematological toxicities experienced by the patients are provided in Table 3. Leukopenia of grade 3 or 4 occurred in eight 32% ; and two 8% ; patients, respectively, and neutropenia of grade 3 or 4 was apparent in seven 28% ; and 10 40% ; patients, respectively; only two patients experienced febrile neutropenia both were treated with granulocyte colony-stimulating factor and i.v. antibiotics ; . No treatment-related deaths were observed. Furthermore, no patients developed thrombocytopenia of grade 3 or 4, and anemia requiring red blood cell transfusion occurred in only one patient. There was no evidence of cumulative hematological toxicity. Neuropathy, arthralgia and myalgia were the most common non-hematological treatment-related toxicities; four patients 16% ; had arthralgiamyalgia of grade 3 and three patients 12% ; had peripheral neuropathy of grade 3, consisting mostly of paresthesia in the hands and feet. Other non-hematological toxicities of grade 3 were uncommon and included fatigue one patient ; . PATIENTS AGED 75 YEARS OR OLDER Given concerns that patients aged 75 years may differ from those aged 7074 years with respect to treatment tolerance and outcome, we compared the response rate and toxicities of grade 3 or 4 between these two age groups. The response rate and tolerance appeared similar in patients of these two age groups Table 4 ; , although the size of both cohorts was relatively small.
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Assets Current assets Cash and cash equivalents Notes 1, 14 and 15 ; Marketable securities Notes 1, 14 and 15 ; Accounts receivable trade, less allowances for doubtful accounts 7 2000, 2 ; Inventories Notes 1 and 2 ; Deferred taxes on income Note 8 ; Prepaid expenses and other receivables Total current assets Marketable securities, non-current Notes 1, 14 and 15 ; Property, plant and equipment, net Notes 1 and 3 ; Intangible assets, net Notes 1 and 7 ; Deferred taxes on income Note 8 ; Other assets Total assets Liabilities and Shareowners' Equity Current liabilities Loans and notes payable Note 6 ; Accounts payable Accrued liabilities Accrued salaries, wages and commissions Taxes on income Total current liabilities Long-term debt Note 6 ; Deferred tax liability Note 8 ; Employee related obligations Note 5 ; Other liabilities Shareowners' equity Preferred stock--without par value authorized and unissued 2, 000, 000 shares ; Common stock--par value .00 per share Note 20 ; authorized 4, 320, 000, 000 shares; issued 3, 119, 842, 000 shares ; Note receivable from employee stock ownership plan Note 16 ; Accumulated other comprehensive income Note 11 ; Retained earnings Less: common stock held in treasury, at cost Note 20 ; 72, 627, 000 and 105, 218, 000 ; Total shareowners' equity Total liabilities and shareowners' equity and betaxolol.
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Hollema H, see Berends MJW Hollenberg PF, see Dhaini HR Hollis D, see Tepper JE Holmberg SB, see Wallgren A Hon C, Kwok AKH, Shek TWH, Au WY. Unusual Locations of Involvement by Malignancies: Bilateral Hypopyon Heralding CNS Relapse of Cutaneous Natural Killer Cell Lymphoma, 3368 Honegger H, see Betticher DC Hong J-H, see Yen T-C Hong WK, see Rudin CM Hood N, see Goodwin PJ Hoogerbrugge N, Bult P, de Widt-Levert LM, Beex LV, Kiemeney LA, Ligtenberg MJL, Massuger LF, Boetes C, Manders P, Brunner HG. High Prevalence of Premalignant Lesions in Prophylactically Removed Breasts From Women at Hereditary Risk for Breast Cancer, 41 Hoon DSB, see Kuo CT see Wascher RA Horai T, see Fukuoka M Horgan A, see Hennessy BT Horgan D, see Weiss MA Horgan KJ, see de Wit R see Hesketh PJ Horning SJ. Something Old, Something Few, Something Subjective, Something Deja Vu editorial ; , 1 ` Horowitz IR, see Bookman MA Horowitz M, see Bierman PJ Horowitz MM, see Serna DS Horsfield MA, see Morgan B Horster S, see Jung CP Hortobagyi GN, see Esteva FJ see Pusztai L see Rivera E see Valero V see Woodward WA Horvath Z, see Lang I Horwich A, see Christian JA see Huddart RA Horwitz EM, see Hanks GE Hoshida Y, see Yamamoto S Hoskins PJ, Swenerton KD, Pike JA, Lim P, Aquino-Parsons C, Wong F, Lee N. Small-Cell Carcinoma of the Cervix: 14 Years of Experience at a Single Institution Using a Combined-Modality Regimen of InvolvedField Irradiation and Platinum-Based Combination Chemotherapy, 3495 Hossfeld D, see Schmoll H-J Hou N, see Kaklamani VG Houghton AN, see Hwu W-J see Segal NH Houldsworth J, see Donadio AC Housman MG, see Lewis JH Houston GA, see Hainsworth JD Houston S, see Johnston SRD Howell A, see Kaufmann M Howes A, see Johnston SRD Hromas RA, see George DW Hruby G, see Featherstone C Hsu C-Y, see Lin J-C Hsueh E, see Chung MH Hsueh S, see Yen T-C Hu H, see Tchen N Hu H-M, see Smith JW II Hu JC, Gold KF, Pashos CL, Mehta SS, Litwin MS. Role of Surgeon Volume in Radical Prostatectomy Outcomes, 401 Huang J, Barbera L, Brouwers M, Browman G, Mackillop WJ. Does Delay and bilberry.
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ABSTRACT Ovarian hyperandrogenism can be associated with insulin resistance, hyperinsulinemia, glucose intolerance, and obesity. High levels of the lipostatic hormone, leptin, have also been reported in this condition. The purpose of the present study was to examine the effect of an oral contraceptive OC ; of low androgenicity containing desogestrel on glucose tolerance in hyperandrogenic women and the impact of changes in androgenic estrogenic status on leptin concentrations. Sixteen nondiabetic hyperandrogenic women, aged 29 1 yr with a body mass index BMI ; of 36.8 1.8 kg m2, underwent an oral glucose tolerance test before and after 6 months of therapy with the OC. Free testosterone decreased and sex hormone-binding globulin increased after therapy P 0.001 ; . Glucose tolerance deteriorated significantly, and two women developed diabetes. Body weight, BMI, and leptin did not change significantly. Leptin correlated with BMI before r 0.56; P 0.02 ; and after r 0.51; P 0.04 ; treatment, but not with glucose, insulin, total and free testosterone, or sex hormone-binding globulin before or after treatment. In conclusion, 1 ; glucose tolerance should be monitored in hyperandrogenic women using OC, even those of low androgenicity; and 2 ; changes in androgenic estrogenic status had no effect on the leptin concentration, suggesting that its sexual dimorphism is not related to sex steroids. J Clin Endocrinol Metab 82: 3074 3077 and betaseron.
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