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5: 28PM KC.00002 Investigation of Fluid Mixing in Channels with Microfabricated Ridges , ZHENG XIA, LOUIS CATTAFESTA, RENWEI MEI, MARK SHEPLAK, Z. HUGH FAN, Department of Mechanical and Aerospace Engineering, University of Florida -- Microflows in complex channels often present unusual flow behavior compared to their macroscale counterparts. Channels with microfabricated ridges are created in a plastic device using photolithography and molding. To study fluid mixing, a novel visualization technique is developed. This approach couples a conventional optical microscope with a computational deconvolution algorithm to produce the images of three dimensional flows, which are obtained by 1 ; optically sectioning the flow in the microchannel by collecting a series of fluorescence images at different focal planes along the optical axis, and 2 ; removing the out-of-focus fluorescence signal by the deconvolution method to reconstruct a corrected three-dimensional concentration image. With the counter interaction of applied pressure and electric potential fields, recirculation in the flow in these ridged channels is observed. The circulation is demonstrated by mixing a fluorescent stream and a water stream in the microchannels, as well as using microparticles. Circulation results in enhanced fluid mixing; the fluorescence intensity variation at the cross section is calculated as an index of mixing. The preliminary results show the rapid mixing in the ridged channels, verifying the existence of circulation. We also compared the experimental results with that from computational fluid dynamics simulation.
Given the fact that only a small percentage of terrestrial plants, marine organisms, fungi, and microbes have been investigated for their chemical content, new natural products of all types are certain to be discovered in the years ahead, and a percentage of these natural products will inevitably contain halogen. With its largely unexplored 500, 000 species in 30 phyla of plants, animals, bacteria, unicellular algae and fungi, the marine world offers the greatest source of new medicines. Fewer than 10% of the 4, 000 species of bryozoans have been investigated for their chemical makeup, and only 20 of the 90 Hawaiian deep-sea gorgonians described thus far have been examined Okuda et al., 1982 ; . The 80, 000 species of molluscs remain substantially untapped for their metabolites. One promising relatively new area of marine exploration are deep water sponges. A study of a small area of the north Jamaican coast at depths between 70-90 meters revealed the presence of 27 sponge species, 10 of which are new to science Lehnert & van Soest, 1996 ; . The incredible diversity of marine life is epitomized by the Great Barrier Reef in Australia. This 100, 000-square mile habitat consists of 2, 500 individual small coral reefs. Around one of these, of less than 14 square miles, there have been identified 930 species of fish, 107 corals, and 154 urchins, cone snails, and other molluscs, to say nothing of sponges, tunicates, and seaweeds Gribble, 1992 ; . Of the 2, 500 recorded nudibranch species, 400500 live on the Great Barrier Reef, and 20 unique species of Staghorn coral are found living together on this reef. It seems clear that a very large number of marine metabolites, halogenated and not, are awaiting discovery. A similar treasure trove will greet the natural products chemist who pursues the thousands of unexplored terrestrial plants, bacteria, fungi and higher animals for novel natural chemicals.
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Giaconda has entered into an underwriting agreement with Findlay & Co Stockbrokers Underwriters ; Pty Ltd dated 2 August 2005 to underwrite the entire Offer. The Underwriter is entitled to appoint sub-underwriters, subject to the reasonable satisfaction of Giaconda, to sub-underwrite such proportion of the Offer as the Underwriter in its absolute discretion thinks fit. The Underwriter is also entitled to terminate the agreement for failures of those underwriters to discharge their obligations as explained below. Fees and Expenses Giaconda will pay the Underwriter an underwriting fee of 4% of the Underwritten Amount plus GST and allot and issue 500, 000 Shares to the Underwriter or its nominee. Reasonable costs and expenses of the Underwriter are to be paid by Giaconda including travel, advertising, printing, marketing and promotional expenditure. Giaconda must also pay the fees of the Underwriter's lawyers, capped at , 000. Warranties Giaconda has given the Underwriter a number of representations and warranties in relation to the Offer. Undertakings Giaconda has given a number of undertakings to the Underwriter, including that: the Offer will proceed according to a timetable.
Bymaster FP, Zhang W, Spencer KA, Feldman PD, Meltzer HY. A novel augmentation strategy for treating resistant major depression. J Psychiatry. 2001; 158: 131-134. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Patient Version. Washington, DC: American Psychiatric Press; 1997. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979; 134: 382-389. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiatry. 1978; 133: 429-435. Spearing MK, Post PM, Leverich GS, Brandt D, Nolen W. Modification of the Clinical Global Impressions CGI ; scale for use in bipolar illness BP ; : the CGI-BP. Psychiatry Res. 1997; 73: 159-171. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959; 32: 50-55. COSTART: Coding Symbols for Thesaurus of Adverse Reaction Terms. 3rd ed. Rockville, Md: Division of Drug and Biological Product Experience, Center for Drugs and Biologics, Food and Drug Administration, Department of Health and Human Services; 1989. Simpson GM, Angus JWS. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand Suppl. 1970; 212: 11-19. Guy W. ECDEU Assessment Manual for Psychopharmacology, Revised. Bethesda, Md: US Dept of Health, Education, and Welfare; 1976. Publication ADM 76-338 ed. Mallinckrodt CH, Clark WS, David SR. Accounting for dropout bias using mixedeffects models. J Biopharm Stat. 2001; 11: 9-21. Mallinckrodt CH, Clark WS, David SR. Type I error rates from mixed-effects model repeated measures compared with fixed-effects ANOVA with missing values imputed via LOCF. Drug Inf J. 2001; 35: 1215-1225. Pope HG Jr, McElroy SL, Keck PE Jr, Hudson JI. Valproate in the treatment of acute mania: a placebo-controlled study. Arch Gen Psychiatry. 1991; 48: 62-68. Bowden CL, Brugger AM, Swann AC, Calabrese JR, Janicak PG, Petty F, Dilsaver SC, Davis JM, Rush AJ, Small JG. Efficacy of divalproex versus lithium and placebo in the treatment of mania: the Depakote Mania Study Group. JAMA. 1994; 271: 918-924. Sachs G, Altshuler LL, Ketter TA, Suppes T, Rasgon N, Frye M, Collins M. Divalproex versus placebo for the treatment of bipolar depression. Paper presented at: 2001 Annual Meeting of the American College of Neuropsychopharmacology; December 10, 2001; Waikoloa, Hi. Peet M. Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants. Br J Psychiatry. 1994; 164: 549-550. Bhana N, Foster RH, Olney R, Plosker GL. Olanzapine: an updated review of its use in the management of schizophrenia. Drugs. 2001; 61: 111-161. Sanger TM, Grundy SL, Gibson PJ, Namjoshi MA, Greaney MG, Tohen MF. Longterm olanzapine therapy in the treatment of bipolar I disorder: an open-label continuation phase study. J Clin Psychiatry. 2001; 62: 273-281. Cohn JB, Collins G, Ashbrook E, Wernicke JF. A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder. Int Clin Psychopharmacol. 1989; 4: 313-322.
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However included for analysis of toxicity. Pathology review was based on histology in 31 of the 32 patients and was confirmed by an expert panel in 29 cases, having definitive of probable malignant mesothelioma. In one case the diagnosis was made on cytology in combination with history and radiology. The histological subtype and most of the major characteristics of the patients are presented in Table 1. Clinical staging of tumors is presented in Table 2. In total 172 cycles of CaelyxTM were given. One patient did not receive any treatment because of early.
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Dictionary of Pharmacovigilance By Amer Alghabban A publication of the Pharmaceutical Press 544 pages. Hardcover. 136.00 ISBN 978-3-7692-3257-8 This Dictionary contains a comprehensive list of abbreviations, terms and phrases in English ; giving definitions of commonly and rarely ; encountered pharmacovigilance terms. Written by someone with excellent knowledge of pharmacovigilance gained from working in industry and regulatory authority. This book will be essential reference for pharmacovigilance and regulatory affairs professionals worldwide and cyanocobalamin.
ANTI - VIRALS ANTIRETROVIRALS AGENERASE CAPS APTIVUS ATRIPLA1 COMBIVIR TABS CRIXIVAN CAPS EMTRIVA EPIVIR HBV EPZICOM FORTOVASE CAPS HIVID TABS INVIRASE CAPS KALETRA LEXIVA NORVIR PREZISTA2 RESCRIPTOR TABS RETROVIR REYATAZ SUSTIVA TRIZIVIR TABS TRUVADA VIDEX EC DIDANOSINE FUZEON Fuzeon use PA Form # 10620 1. Quantity limit of per per day 2. Only preferred if Norvir script is in member's profile within past 30 days of filling Prezista
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In general, Canadian courts have had difficulties reconciling the concepts of aboriginal rights with the rest of Canadian law. There were previous attempts to classify aboriginal rights by applying pre-existing legal concepts from English property law. This has been re-evaluated, and these attempts have been abandoned. The law now accepts that aboriginal rights are unique, that they are sui generis 1112 . This means that the case law and the definitions evolve slowly on a case by case basis. It is largely understood that this perspective provides opportunities to develop a more sensible understanding of those rights. 1113 The first time this uniqueness of aboriginal rights was emphasised was in the Guerin case. 1114 That case concerned aboriginal title and stood for the proposition that title represented a unique interest in land. The Court stated that previously, the courts had almost inevitably applied a somewhat inappropriate terminology drawn from general property law. Instead, the aboriginal interest in lands was sui generis. 1115 The sui generis nature of aboriginal rights has since been confirmed in many cases, for instance in Sparrow and Delgamuukw. In Sparrow, the Court noted that courts must be careful to avoid application of traditional common law concepts of property as they develop an understanding of the sui generis nature of aboriginal rights. Since it is impossible to give an easy definition of aboriginal rights, it is crucial to be sensitive to the aboriginal perspective on the meaning of the rights at stake. As an example, the Court meant that it would be artificial to create a firm distinction between the right to fish and.
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Ofindicators for detecting impacts o : 1 ; changes i climate, 2 ; f n land use, 3 ; pollution, 4 ; alien 5 n species, and ; carbon dioxide concentration. T h e items i this preliminary list were then discussed according t criteria based on feasibility and information content easy t use and with i o o high information content; easy t use but with limited information content; difficult t do but o o with high information content; and difficult t do and uith limited information content ; . o Vascular plant species cover abundmce w a s found t be the most useful and easily recorded o indicator for a l drivers. It was noted that m a n other generic indicators could be used t indicate l o changes i more than one driver. O the generic indicators such as vasculnr plaiits \'egetatioii n f o cover, a specific set \voald be required t detect the impacts ofchmges i the different drivers. It w a As0 noted thx on cultivated land, the overriding impact \vas land use and there u7cre fe\v indicators that could be usecl globcilly.A system bised on standardized observations o indicator f crop species \vasproposed f r a long-term study o climate. o f Well-established systematic long-term observation studies, such as GLORIA Pauli et al., 2004 ; , nith a potential t serve as a modcl fr application in hL4B Biosphere Reserves are rue. o o T selection ofindicators and evaluation of their applicability altitude zone, geographic extent ; , usefdness, feasibility, priority use, clriver sensitility, cost equipment, labour ; , availability of published methodology, current o past qplication, and required fi-equency of d; ita collection i r s but one essential step i designing a long-term obscrvation system. Such a system \vould need t n o take into : iccoiint a number ofconsiclcrationsIvith regard t designing data collection, analysis and o o system maintenance. W e now need t consider a11 these aspects and use aviilcibleexperience e.g. GLORIA, o r the relev, int features of the U K ECN ; and the increasing liter~ture the theoretion c d and practical aspects of designing and running long-term observation studies in terrestrial s: .y o ecosystems.There i i long na t go before the standardization ofthe methodology fr terrestrial ccosysteni observation reaches the Ievels a\.nil: ible f r glaciology or hydrology o and cylert.
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Replacement insurance, the insured must produce documentation at the hearing which will allow comparison of coverages and costs between the original policy and the replacement policy. Following the hearing and receipt of the stenographic transcript, the Commissioner will issue a written order resolving the factual issues presented at the hearing and stating what remedial action, if any, is required. The Commissioner's Order will be sent to those persons participating in the hearing or their designated representatives. The Order of the Commissioner may be subject to judicial review by the Commonwealth Court. Persons with a disability who wish to attend the previously referenced administrative hearing and require an auxiliary aid, service or other accommodation to participate in the hearing, should contact Tracey Pontius, Agency Coordinator at 717 ; 787-4298. M. DIANE KOKEN, Insurance Commissioner and crixivan.
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