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Abbreviations used are: MAb, monoclonal antibody; P-450, cytochrome P-450; DZ, diazepam; 7-EC, 7-ethoxycoumarin; IMI, imipramine; HLM, human liver microsome; DIM, desipramine; TMZ, temazepam; NDZ, nordiazepam; 2-OH IMI, 2-hydroxyimipramine; HPLC, high-performance liquid chromatography; IB, immunoblot. Send reprint requests to: Dr. H. V. Gelboin, Bldg. 37, Rm 3E24, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892.
Protection from BCNU-induced DNA damage observed at higher concentrations of BCNU may be due to 1 ; enzyme saturation of either FPG hOGG1 or any of its downstream repair enzymes or 2 ; non-FPG hOGG1-repairable DNA damage, such as O6-alkylguanine, contribute more to the damaging effect of BCNU than N7-alkylguanines. Although FPG and hOGG1 are functional homologues, in the current study, FPG exhibited a stronger protective effect against BCNU toxicity than hOGG1. This finding is consistent with a previous study that shows hOGG1 only partially suppresses the spontaneous mutator phenotype of FPG-deficient E. coli strains 28 ; . A possible explanation comes from a recent study, which shows an increased amount of Ape1 stimulates the activity of hOGG1 through enhancing hOGG1 turnover 14 ; . In this case, solely over-expressing hOGG1 without up-regulating Ape1 may not increase this specific DNA repair activity. On the other hand, there is no similar report on FPG. In addition, FPG and hOGG1 may have different substrate.
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These days you can't step out your front door without knocking over some wannabe contortionist: left knee bracketed over trapezius; right leg wrapped across and around left buttock; head poking out at mid solar plexus; velvet tip hat simpering between gritted grinning teeth. It's the epidemic no one wants to talk about. Easier to just step around them, and go on with your day. Across from my office, one is wrapped in cellophane and green tights ostensibly miming the decline of refrigerated vegetables. Beside him another is motionless--arms raised, one knee cocked--in a vintage brass diving suit. Out on the corner of 22nd and 2nd some lone brave has been reenacting the Seminole resistance for the past six weeks, lingering voluptuously over Osceola's equivocal end. Down by the bus station some piker takes it easy: Washington crossing the Delaware. Sure money. They want to make us uncomfortable and they want us to love them for it. And they want tips. I understand that: puppets or puzzles, makes no difference to me. It's only the proliferation that annoys me. These days everyone who isn't one is two degrees away from one or related to one. Mikey wanted to be an alligator farmer. He had it all figured out. He'd get at it a few different ways: slaughter some and sell them to restaurants and tailors; keep some for wrestling and tourists; maybe rent some out to zoos and little fairs. He'd gone to visit his grandparents in Miami and come back with a whole career path. Of course, we were eleven years old at the time. That was the same summer we were locked in daily battle with two farm brothers--John and Jay--like it was our.
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DISCLOSURES This study was supported by grants from the Department of Veterans Affairs and National Institute of Diabetes and Digestive and Kidney Diseases DK-56061 and DK-58057 ; . J. C. Reidling is a ajpcell.
Can greatly improve your quality of life. They work by coating the bone and blocking the activity of the cells involved in bone damage. These drugs include Zometa, Bonefos and Aredia. Bisphosphonates may also affect myeloma cells too, preventing their growth and survival. Bisphosphonates can be taken orally as tablets daily or by intravenous injection, usually once a month. Usually they are a long-term treatment. They can also help to lower raised calcium levels in your blood. See page 50 for the side-effects of bisphosphonates. Before treatment your doctor may recommend that you get a dental check-up, as bisphosphonates may cause some jaw problems. Surgery: Depending on the severity of your bone disease, you may need orthopaedic surgery. This is done to repair any fractures in the bones of your spine vertebrae ; or to strengthen them. New surgical techniques are being developed all the time. For example, vertebroplasty involves shaping the bone when it has collapsed due to a fracture. After surgery you may need physiotherapy for some time too. Radiotherapy: Radiotherapy can strengthen bone and reduce pain in the affected areas. It involves aiming careful doses of highenergy radiation at a site of bone damage and pain. It can also be used at the site where a myeloma tumour plasmacytoma ; has been removed. The use of radiotherapy to a specific area can kill myeloma cells quicker than chemotherapy and with fewer sideeffects. There are several different ways of giving radiotherapy. Often it is given daily for one or more weeks, but once or twice a week courses or even single treatments are also used. For more information on radiotherapy, contact the National Cancer and glucagon.
Termination for Good Reason . Except where Section 2.20 e ; is applicable, this Section 7.6 shall only become effective when at least twelve 12 ; months have elapsed since the Employment Date. Prior to this Section 7.6 becoming effective, any notice of termination by Executive may only be given pursuant to Section 7.3. The Executive shall have sixty 60 ; days from the date he learns of action taken by the Company that allows the Executive to terminate his employment for Good Reason to provide the Board with a Notice of Termination. 11.
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Active Ingredients GLIADEL Implants contain 7.7 mg of carmustine as the active ingredient. Other Ingredients The other ingredient in GLIADEL Implants is an inactive copolymer called Polifeprosan 20. This copolymer consists of two polymers - carboxypropane and sebacic acid. Sponsor Orphan Australia Pty Ltd 48 Kangan Drive Berwick Victoria 3806 Australia ARTG number: AUST R 77283 Date of Preparation: 21 June 2002.
Churchill Livingstone, 1983; 331-333. Crumrine RS, Nulsen FE, Weiss MH. Alterations in ventricular fluid pressure during ketamine anesthesia in hydrocephalic children. Anesthesiology 1975; 42: 758761. Mitchel AA, Louik C. Lacouture P. Slone D, Goldman P. Shapiro S. Risks to children from computed tomographic scan and glycopyrrolate.
And private insurers to regional health authorities and down to individual hospitals, and within hospitals from the central administration and the department head through to the individual physician in hospital. One cannot make a costeffectiveness argument for all of them! Industry faces many difficulties. First, there are problems of timing and research in cost assessment. Assessing innovative devices at introduction is difficult. These are fast-changing technologies with continuous incremental improvement. There are learning curves for physicians or nurses. We need real-life experience, because effectiveness depends on the user of the device, and we need interaction between users and manufacturers. Researchers face new questions of effectiveness and cost-effectiveness. Collaboration early on when products are being developed must include discussions between policy makers and the device industry, so that industry knows what questions will be looked at. The patient population often constitutes another problem for decision makers looking at data. We are not just treating rare diseases, but it often feels like it, with small patient populations devices are often invasive and last-resort ; . Patients are often unwilling to go into medical device studies, especially of interventional therapies and particularly RCTs ; they either want intervention or not, and in each case do not wish to be randomised to the other arm. Referring physicians do not send patients for study. On the other hand, it is also very costly to do large studies that include surgery. Problems remain with study design and clinical evidence. RCTs are considered the gold standard, but they might be impossible or unethical, or unnecessary when the effect of the therapy is so large that it cannot be caused by confounding factors. RCTs may be inappropriate when patient populations are too small or when the outcomes are so distant. RCTs may be inadequate if they do not apply to the whole patient population. And then when submitting dossiers industry is asked to provide clinical data published or on file. Health Technology Assessment HTA ; agencies often see the very fact of industry sponsorship as a bias. There is also a "publication bias": HTA agencies often require only published data, but it can also be difficult to get data published, even if you want to. Why not use unpublished data, confidentially, without compromising later publication? Requirements for evidence of cost-effectiveness differ from country to country. It would be best to take a societal perspective, where all costs and benefits are taken into account, because in the end we all want to save money overall. The health service perspective is another valid approach costs and benefits within the national healthcare system ; . But silo budgets are too restrictive. I read yesterday a document from the Belgian health minister with a two-line comment saying 62.
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The Canadian Institute of Chartered Accountants approved a new Handbook Section 3062 - Goodwill and Other Intangible Assets. Intangible assets other than goodwill acquired in a business combination or other transaction for which the acquisition date is after June 30, 2001, are to be amortized based on the useful life to an enterprise, unless the life is determined to be indefinite in which case the intangible asset will not be amortized. Section 3062 will be effective for the Company's fiscal year beginning January 1, 2002. The Company does not believe the adoption of this section will have a material impact on the financial statements. The Canadian Institute of Chartered Accountants approved a new Handbook Section 3870 - Stock Based Compensation and Other Stock - Based Payments. Section 3870 will be effective for the Company's fiscal year beginning January 1, 2002. The Company does not believe the adoption of this rule will have a material impact on the financial statements. 10 and goldenseal.
Electroencephalography EEG ; was performed using silver silver chloride scalp electrodes including T1 T2 electrodes. EEG with re-build-up phenomenon after hyperventilation was found in all patients. HV was usually done for about three minutes. If a marked re-build-up phenomenon was seen earlier, HV was stopped immediately.
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BOYCE, P. R., 1977, Investigations of the subjective balance between illuminance and lamp colour properties, Lighting Research and Technology, 9, 11-24. BOYCE, P. R., 1994, Is full-spectrum lighting special? In J. A. Veitch Ed ; , Full-spectrum lighting effects on performance, mood, and health, IRC Internal Report No. 659 National Research Council of Canada, Institute for Research in Construction, Ottawa, Canada ; , 30-36. BOYCE, P. R., 1996, Illuminance selection based on visual performance - and other fairy stories. Journal of the Illuminating Engineering Society, 25 2 ; , 41-49. BOYCE, P. R., 1998, Lighting quality: The unanswered questions. In J. A. Veitch Ed. ; , Proceedings of the First CIE Symposium on Lighting Quality, CIE x015-1998 Commission Internationale de l'Eclairage [CIE], Vienna, Austria ; , 72-84. BOYCE, P. R. and CUTTLE, C., 1990, Effect of correlated colour temperature on the perception of interiors and colour discrimination performance, Lighting Research and Technology, 22, 19-36. BOYCE, P. R. and REA, M. S., 1994, A field evaluation of full-spectrum, polarised lighting, Journal of the Illuminating Engineering Society, 23 2 ; , 86-107. BOYCE, P. R. and SIMONS, R. H., 1977, Hue discrimination and light sources, Lighting Research and Technology, 9, 125-140. BRAINARD, G. C., BEACHAM, S., HANIFIN, J. P., SLINEY, D., AND STRELETZ, L., 1992, Ultraviolet regulation of neuroendocrine and circadian physiology in rodents and the visual evoked response in children. In F. Urbach Ed. ; , Biological responses to UVA radiation Valdenmar Publishing, Overland Park, KS ; , 261271. BUTLER, D. L. and BINER, P. M., 1987, Preferred lighting levels: Variability among settings, behaviours, and individuals, Environment and Behavior, 19, 695-721. CAMERON, J. T., 1986, January February, John Ott: The "light" side of health, The Mother Earth News, No. 97, 1722. CHANCE, R. E., 1983, The effects of two ranges of fluorescent lighting spectra on human physical performance, Dissertation Abstracts International, 43, 2862B. University Microfilms No. DA8302215 ; . CHARTERED INSTITUTION OF BUILDING SERVICES ENGINEERS CIBSE ; 1994, Code for interior lighting CIBSE, London, UK ; . CLEAR, R. and MISTRICK, R. G., 1996, Multilayer polarizers: A review of the claims, Journal of the Illuminating Engineering Society, 25 2 ; , 70-88. COCKRAM, A., H., COLLINS, J. B. and LANGDON, F. J., 1970, A study of user preferences for fluorescent lamp colours for daytime and night-time lighting, Lighting Research and Technology, 2, 249-256. COOK, D., 1994, March April, A case of daylight robbery, Psychology Today, 27 2 ; , 8. CORTH, R., 1983, March, The impact of lighting on health, Proceedings of the National Symposium on Lighting Design for Hospitals Health and Welfare Canada, Ottawa, Canada ; , 59-66. DIAPER, G., 1990, The Hawthorne Effect: A fresh examination, Educational Studies, 16, 261-267. ERIKSON, C. and KULLER, R., 1983, Non-visual effects of office lighting, Proceedings of the 20th Session of the Commission Internationale de l'clairage, CIE, Vienna, Austria ; , D602 1-4. ESPIRITU, R. C., KRIPKE, D. F., ANCOLI-ISRAEL, S., MOWEN, M. A., MASON, W. J., FELL, R. L., KLANBER, M. R. and KAPLAN, D. J., 1994, Low illumination experienced by San Diego adults: Association with atypical depressive symptoms, Biological Psychiatry, 35, 403-407. FERGUSON, R. V. and MUNSON, P. A., 1987, The effects of artificial illumination on the behaviour of elementary school children, Final report to Extramural Research Programs Directorate Health Services and Promotions Branch Health and Welfare Canada University of Victoria, School of Child Care, Victoria, B.C., Canada ; . FOOD AND DRUG ADMINISTRATION 1986, September 10, Lamp's labeling found to be fraudulent, FDA Talk paper T86-69 US Department of Health and Human Services. Rockville, MD, USA ; . FOTIOS, S. A. and LEVERMORE, G. J., 1995, Visual perception under tungsten lamps with enhanced blue spectrum, Lighting Research and Technology, 27, 173-179. FREDRICKSON, B. L., 1998, What good are positive emotions? Journal of General Psychology, 2, 300-319. GIFFORD, R., 1994, Scientific evidence for claims about full-spectrum lamps: Past and future. In J. A. Veitch Ed ; , Full-spectrum lighting effects on performance, mood, and health, IRC Internal Report No. 659 National Research Council of Canada, Institute for Research in Construction, Ottawa, Canada ; 37-46. GIFFORD, R., 1997, Environmental psychology: Principles and practice, 2nd ed, Allyn and Bacon. Boston, USA.
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Keywords: Newton algorithms, fluid-structure interaction. Participants: Patrick Le Tallec, Marina Vidrascu. This work is done in collaboration with Jean-Frdric Gerbeau4 . The objective is to simulate the mechanical interaction between the blood and the wall of large arteries. Due to the so-called "added mass effect", this problem differs physically and algorithmically ; from other classical fluid-structure problems aero-elasticity ; , as its stability strongly depends on the accuracy of the resolution of the fluid-structure coupling at each time step. Specifically, this means that an accurate energy balance must be achieved at each time step, hence it is mandatory to solve the coupling by implicit schemas. The resulting non-linear fluid-structure problem is difficult to solve. This year we validated the reliability of the coupled algorithm on rather realistic configurations such as a carotid obtained from medical images and an aneurism. The actual algorithm is robust but nevertheless there is a limitation in the size of the problems that we can solve. This is due to the fact that at each step the nonlinear shell problem is solved by a direct method. This is mandatory due to the condition number. In order to overcome this restriction it is necessary to develop different solution methods and granisetron.
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FIG. 2. Serum GH concentration profiles in 26 subjects during two-step GH infusion and concomitant continuous iv infusion of octreotide 2 g 1.73 m 2 h ; Each infusion period was preceded by a bolus injection of 20 g indicated by arrows ; . A, On study d 1 the infusion rates were calculated according to body weight infusion period 1, 1.5 g kg h; infusion period 2, 3.0 g kg h ; study d 2 the infusion rates were calculated according to intraabdominal fat area infusion period 1, 0.9 g cm 2 intraabdominal fat h; infusion period 2, 1.8 g cm 2 intraabdominal fat h and grepafloxacin.
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