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The ratio of FDG uptake to blood flow on matching images was obtained for the LAD region and expressed as a ratio of the non-LAD region at the two time points. Figure 2 shows matching images of myocardial blood flow MBF ; and FDG from one pig after stunning. In this animal, FDG uptake in the LAD distribution was higher than perfusion, at a time that a severe wall motion abnormality was observed. The extent of enhanced FDG MBF in the LAD region when normalized to remote areas is shown for all animals at 1 and 7 days postreperfusion Fig. 3 ; . Although seven measurements were available at both time points, only six animals had paired measurements. The ratios at Days 1 and 7 were 1.29 0.16 and 1.09 0.08, respectively, which, by paired Student's t-test, was significant p 0.07 ; . When independent Student's t-test was used, however, the differences with all measurements were p 0.01.
Silva, P., Slevin, N., Sloan, P., Price, P., West, C., Homer, J., Hampson, I. and Hampson, L. 2006 ; The role of lung resistance protein in radiation treated head and neck carcinoma. Clin Otolaryngol, 31, 247. West, C. and McKeown, S. 2006 ; Translational research in radiotherapy trials. Br J Radiol, 79, 716718.
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Improving the Access of MERCOSURs Agriculture Exports to US: Lessons from NAFTA English ; . Pablo Sanguinetti and Eduardo Bianchi. INTAL-ITD WP-18. 2004. Premio INTAL - Segundo Concurso de Ensayos. La coordinacin macroeconmica y la cooperacin monetaria, sus costos, beneficios y aplicabilidad en acuerdos regionales de integracin Spanish, English and Portuguese ; . Mauricio de la Cuba; Diego Winkelried; Igor Barenboim; Louis Bertone; Alejandro Jacobo and James Loveday Laghi. INTAL-ITD DT-17. 2004. Agricultural Exporters in a Protectionist World: Review and Policy Implications of Barriers Against Mercosur English ; . Julio J. Nogus. INTAL-ITD WP-16. 2004. Rules of Origin in FTAs in Europe and in the Americas: Issues and Implications for the EU-Mercosur Inter-Regional Association Agreement English ; . Antoni Estevadeordal and Kati Suominen. INTAL-ITD WP-15. 2004. Regional Integration and Productivity: The Experiences of Brazil and Mexico English ; . Ernesto Lpez-Crdova and Mauricio Mesquita Moreira. INTAL-ITD-STA WP-14. 2003. Regional Banks and Regionalism: A New Frontier for Development Financing English ; . Robert Devlin and Lucio Castro. INTAL-ITD-STA WP-13. 2002. Mtodos casusticos de evaluacin de impacto para negociaciones comerciales internacionales Spanish ; . Antonio Bonet Madurga. INTAL-ITD-STA DT-12. 2002. Las trabas no arancelarias en el comercio bilateral agroalimentario entre Venezuela y Colombia Spanish ; . Alejandro Gutirrez S. INTAL-ITD-STA DT-11. 2002
What exists in contemporary Iraq is an empire of lies and violence. Nowhere is this more evident than in the manufactured hagiography cultivated around an idealized figure of Hussein. He is presented to Iraqis as the leader of all Arabs, a descendent of the prophet Mohammed. He has been built up as a leader in all fields: the first doctor, the first artist, the brilliant and brave ruler who has defeated all imperialists, including the United States of America. Anyone journalist or otherwise who fails to portray Hussein in this light puts his life on the line. Absolutely no criticism of the regime is tolerated. And the price paid by anyone who speaks can be vicious. In a particularly grisly incident last February, two Iraqis in the city of Hilla, about 100km from Bagdad, reportedly had their tongues cut out pub ATLAPEDIA ONLINE and invirase.
The activities of dissemination and information are channeled through three different action lines: the services of the INTAL Documentation Center CDI databases and other information systems; and the Institute's publications. As regards the services of the CDI, statistical data on its tasks clearly reveal the intensity of the Center's work in 1999. In that respect, the most notable of its tasks were as follows: The CDI undertook 240 bibliographical searches on specific topics at the request of users resident abroad growth rate, 98-99: 500.
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In interleukin-6 knock-out mice: a causal role of IL-6 in the development of the low 3, 5, 3 -triiodothyronine syndrome. Endocrinology 137: 5250 5254 Darras VM, Berghman LR, Vanderpoorten A, Kuhn ER 1992 Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver. FEBS Lett 310: 5 8 Vasilatos Y, Zhou Y, Wang X, McMurtry J, Rosebrough R, Decuypere E, Buys N, Darras V, Van der Geyten S, Tomas F 2000 Altered chicken thyroid hormone metabolism with chronic GH enhancement in vivo: consequences for skeletal muscle growth. J Endocrinol 166: 609 620 Moller J, Jorgensen J, Moller N, Christiansen J, Weeke J 1992 Effects of growth hormone administration on fuel oxidation and thyroid function in normal man. Metabolism 41: 728 731 Berry M, Kates A, Larsen P 1990 Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol 45: 743748 Tabata S, Nishikawa M, Toyoda N, Yonemoto T, Ogawa Y, Inada M 1999 Effect of triiodothyronine administration on reduced expression of type 1 iodothyronine deiodinase messenger ribonucleic acid in streptozotocin induced diabetic rats. Endocr J 46: 367374 and iressa.
The problems of the rules of origin in the Free Trade Areas FTAs ; in Europe and the Americas as well as their possible implications for the European Union EU ; MERCOSUR Inter-regional Association Agreement are the core issues of Working Paper No. 15 published this month, within the INTAL-ITD series. The main purpose of this study by Antoni Estevadeordal and Kati Suominen is to provide a detailed mapping of the different rules of origin in force on both sides of the Atlantic to analyze the effects they will have on the inter-regional relations emerging from a possible agreement between the EU and MERCOSUR. No doubt the rules of origin will be the focus of the forthcoming rounds of negotiations for the EU-MERCOSUR agreement. Anyhow it is a decisive aspect of the Free Trade Area of the Americas FTAA ; negotiations and an increasingly important one for the World Trade Organization WTO ; given the interest in harmonizing these regimes globally. The document approaches these topics in four sections. The first talks about the different rules of origin in trade agreements whether these are general or specific to some products- and discusses their use in the different current regimes. The second section focuses on the structure of the regimes in Europe and the Americas, including an evaluation of the restrictions noted on both sides of the Atlantic. The third section looks into trade relationships between the European and South American blocs, assessing their immediate effects and submitting long-term projections for MERCOSUR operations according to different rules of origin scenarios, either in Europe or the Western Hemisphere. The fourth and last section provides conclusions on research and policy recommendations stemming therefrom. The authors argue that just like in the EU-Mexico and EU-Chile agreements, the European's standardized regime of origin will play a central role in negotiations that will take place in this field with the MERCOSUR. The grounds sustained aim at stating that, in the latter case, an already established model will be taken as a reference instead of developing a regime tailored to EU-MERCOSUR trade relations. However, it is acknowledged that MERCOSUR has room to maneuver in order to obtain its preferred rules for specific products even when these may deviate from European standards. The fact that MERCOSUR is carrying out integration negotiations within two schemes which envisage the application of broadly accepted rules of origin regimes such as those of the EU and FTAA- contributes to avoiding a situation in which the South American bloc becomes part of several free trade agreements with different rules of origin. The latter, plus the fact that the European regime is expanding geographically and that the FTAA will have uniform rules of origin, leads the authors to think that there is a global movement towards the application of relatively similar rules of origin. The movement in this direction is in turn favored by the simplicity of regimes applied in Asia-Pacific and Africa, often with the same rules of origin. The document concludes by considering that WTO has moved forward in the harmonization of non-preferential rules of origin at the global level and that the Doha Round must leverage this situation to complete the task as well as promote multilateral agreements which promote the process of harmonizing preferential rules of origin. This document is available in PDF format in English under the title Rules of Origin in FTAs in Europe and in the Americas: Issues and Implications for the EU-MERCOSUR Inter-Regional Association Agreement at: : iadb intal ingles i-default and or at : iadb int.
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Depending on the severity of asthma, medications can be taken on an as-needed basis prn ; or regularly to prevent or decrease breathing difficulty. Most of the medications fall into two major groups: quick relief medications; and long-term control medications. Quick Relief MedicationsQuick relief medications are used to treat asthma symptoms or an asthma episode. The most common quick relief medications are the short-acting beta-agonists that relieve asthma symptoms by relaxing the smooth muscles around the airways. Common beta-agonists include Proventil and Ventolin albuterol ; , Maxair pirbuterol ; , and Alupent metaproterenol ; . Atrovent ipatroprium ; , an anticholinergic, is a quick relief medication that opens the airways by blocking reflexes through nerves that control the smooth muscle around the airways. Steroid pills and syrups, such as Deltasone prednisone ; , Medrol methylprednisolone ; , and Prelone or Pediapred prednisolone ; are very effective at reducing swelling and mucus production in the airways; however, these medications take 6-8 hours to take effect. Long Term MedicationsLong-term control medications are used daily to maintain control of asthma and prevent asthma symptoms. Intal cromolyn sodium ; and Tilade nedocromil ; are long-term control medications which help prevent swelling in the airways. Inhaled steroids are also long-term control medications. In addition to preventing swelling, they also reduce swelling inside the airways and may decrease mucus production. Common inhaled steroids include Vanceril, Vanceril DS, Beclovent, and Beclovent DS beclomethasone ; , Azmacort triamcinolone ; , Aerobid flunisolide ; , Flovent fluticasone ; and Pulmicort budesonide ; . Leukotriene modifiers are medications that can help reduce daily symptoms. They may reduce swelling inside the airways and relax smooth muscles around the airways. Common leukotriene modifiers include Accolate zafirlukast ; , Zyflo zileuton ; and Singulair muntelukast ; . Another longterm control medication, Theophylline, relaxes the smooth muscle around the airways. Common theophyllines in oral form include Theo-Dur, Slo-Bid, Uniphyl and UniDur. Serevent salmeterol ; , in inhaler form, is also a long-term control medication. As a long-acting betaantagonist, it opens the airways in the lungs by relaxing smooth muscle around the airways. There are combination salmeterol and cantrostrol inhaled medications Advair ; that are available. Inhaled Medications Inhaled medications are delivered directly to the airways, which is useful for lung disease. Aerosol devices for inhaled medications may include the metered-dose inhaler MDI ; , MDI with spacer, breath activated MDI, dry powder inhaler or nebulizer. The most commonly used inhaled medications are delivered by the MDI, with or without the spacer. There are few side-effects because the medicine goes right to the lungs and not to other parts of the body. It is critical that the patient use the prescribed MDI correctly to get the full dosage and benefit from the medication. Unless the inhaler is used in the right manner much of the medicine may end up on the patient's tongue, the back of their throat, or in the air. Use of a spacer or holding chamber helps significantly with this problem and their use is strongly recommended. A spacer is a device that attaches to a MDI and holds the medication in its chamber long enough for the patient to inhale it in one or two slow deep breaths. This eliminates the possibility of inadequate medicine delivery from poor patient technique.
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Because human pituitary gonadotrope cells were unavailable to us, we used the mouse T3-1 pituitary tumor cell line as an experimental model to study the transcription regulation of the human GnRHR gene 9, 33, 35 ; . The expression of GnRHR mRNA from the JEG-3 cells indicated the feasibility of using these cells to study the regulation of the human GnRHR gene 7 ; . We have observed a P-induced decrease in human GnRHR promoter activity in pituitary cells. This observation was in agreement with the results obtained from the studies in the ovine showing that P negatively regulates the expression of the GnRHR gene. Interestingly, this P-induced inhibition of human GnRHR promoter activity could not be observed in the placental JEG-3 cells, which also possess the GnRH-GnRHR system 7, 48 ; . Instead, using RU486 to block endogenous P action and AGT to inhibit P production resulted in a decrease in human GnRHR promoter activity, suggesting the importance of P in maintaining the expression of GnRHR at the placenta. GnRH has been shown to stimulate the secretion of hCG from the placenta 5 ; , which is important in maintaining early pregnancy by stimulating P production from the cor and isdn.
DOSAGE AND ADMINISTRATION: The usual StartIng Dosage for adults and children 5 years of age and over is the contents of one INTAL cromolyn sodlum ; capsule inhaled four timesdaily at regular Intervals using a SPINHALER turbo-inhaler. Because INTAL and the Spinhaler represent a different approach to the treatment of asthma, careful explanation and Instruction in the use of the Spinhaler should be given to each patient. Please see the instructions for the use of the Spinhaler included with the device. ; It should b. emphasized the patient th.t th, drug Is not absorbed when swallowed and Is not eftectlve by thIs rout. of edmInIstratIon. Patients should be advised that the effect of INTAL therapy Is dependent upon its administration at regular intervals, as dIrected. INTAL should be introduced into the patient's therapeutic regimen when the acute episode has been controlled, the airway cleared and the patient is able to inhale adequately. INTAL has no role in the treatment of an acute asthma attack especially status asthmatlcus. Once a patient is stabilized on INTAL, if there is no need for steroids, the frequency of administration may be titrated downward to the least frequent level consistent with the desired effect. The usual decrease is from four to three INTAL capsules per day. It is important that the dosage be reduced slowly, maintaining close supervision of the patient, to avoid exacerbationof asthma. Itshould beemphasized that In patients who have been titrated to less than four capsules per day, an increase in dosage may be needed If the patientS clinical condition worsens.
These growth rates were calculated using the export price indexes published in the UN's International Trade Statistics Yearbook. Even so there still remain problems of comparability as not all countries adopted the HS, used as the basis for classifying exports in the INTAL trade database according to ISIC, at the same time. Most of the countries of South America did so starting in 1989, 1990 or 1991, however the Central American countries and Uruguay began to classify their exports following the HS in 1993, and Costa Rica and Panama adopted it as recently as 1994 and 1995, respectively. Given their relative size this probably does not significantly alter the analysis of the composition of exports at the Latin American level and isradipine.
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Hyperactivity: Why Won't My Child Pay Attention? : amazon exec obidos ASIN 0471533076 schwabfoundation By Sam Goldstein, Ph.D. and Michael Goldstein M.D. Overcoming Underachieving: An Action Guide to Helping Your Child Succeed in School : amazon exec obidos ASIN 0471170321 schwabfoundation By Sam Goldstein, Ph.D. and Nancy Mather, Ph.D. editors ; When You Worry about the Child You Love: Emotional and Learning Problems in Children : amazon exec obidos ASIN 0684832682 schwabfoundation By Edward M. Hallowell, M.D.
Using the composite binding pocket, a series of phenyl, heterocyclic and alicyclic ring-containing thiourea NNRTIs were synthesized that yielded high binding affinity for HIV-1 RT and robust anti-HIV activity against wild-type and drug-escape mutants.21, 44, 64, 6976 The thiourea NNRTIs were more potent against drug-sensitive and multidrug-resistant strains of HIV-1 than the three classes of NNRTIs currently in clinical use to treat HIV infections.6976 Representative thiourea NNRTIs under development as molecular virucidal microbicides include and ivermectin.
For 30 min following the basal period, after which, STa plus genistein or herbimycin A was perfused for an additional 30 minutes. The segment was then gently flushed to remove residual stimulatory agents, and bicarbonate secretion was measured for an additional 45 minutes. After each experiment, the length of the duodenal test segment was measured in situ to the nearest 0.5 mm. As shown previously, animals could be sustained for more than 3 hours under these experimental conditions 25 and intal.
And they laid hands on her, and she went the way that the horses of the kings went out and was slain there. And Jehoiada made a bond both between the Lord and the king, and between the people and the Lord, that they should be the Lords people: and also between the king and the people. Then all the people of the land went into the house of Baal, and destroyed his altars, and brake down his Images lustily, and slew Nathan the priest of Baal before the altar. And the priest set watchmen in the house of the Lord, and took the rulers over hundreds and the captains and the guard and all the people of the land: And they brought the king from the house of the Lord and went the way of the gate of the guard of the kings house. And he sat him down on the seat of the kings. And all the people of the Lord rejoiced, and the city was in quiet. And they slew Athaliah with the sword in the house of the king. [Chpt 12] Jehoas was seven years old when he was made king. And he began to reign the seventh year of Jehu, and reigned forty year in Jerusalem. His mothers name was Zebiah Bersabe. And he did that pleased the Lord, as long as Jehoiada the Priest informed him. But they took not away the hill altars, for the people slew and offered still in the hill altars. And Jehoas said to the priest: all the silver that is dedicate and brought to the house of the Lord in current money, that is to say, the money that every man is set at, with all the money that every mans heart giveth him to bring into the house of the Lord, let the priests take it to them, every man of his acquaintance, and let them repair the broken places of the temple in all the places where ought is found decayed. Neverthelater the priests had not mended unto the twenty third year of Jehoas, that was decayed in the temple. Then and kaletra.
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Plasma renin activity and plasma aldosterone in essential hypertension. J Clin Endocrinol Metab 46: 220, 1978 Williams GH, Hollenberg NK: Accentuated vascular and endocrine response to SQ 20881 in hypertension. N Engl J Med 297: 184, 1977 Gavras H, Brunner HR, Laragh JH, Sealey JE, Gavras I, Vukovich RA: An angiotensin converting enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients. N Engl J Med 291: 817, 1974 Liang C, Gavras H, Hood WB: Renin-angiotensin system inhibition in conscious sodium-depleted dogs: effects on systemic and coronary hemodynamics. J Clin Invest 61: 824, 1978 Case DB, Wallace JM, Keim HJ, Weber MA, Sealey JE, Laragh JH: Possible role of renin in hypertension as suggested by renin-sodium profiling and inhibition of converting enzyme. N Engl J Med 296: 641, 1977 Dempsey PJ, McCallum ZT, Kent KM, Cooper T: Direct myocardial effects of angiotensin 11. J Physiol 220: 477.
62. Frustaci A, Chimenti C, Bellocci F, et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 1997; 96: 11804. Bharti S, Lev M. Histology of the normal and diseased atrium. In: Fall RH, Podrid PJ, eds. Atrial Fibrillation: Mechanism and Management. New York: Raven Press; 1992. p1539. 64. Bailey GW, Braniff BA, Hancock EW, et al. Relation of left atrial pathology to atrial fibrillation in mitral valvular disease. Ann Intern Med 1968; 69: 1320. Xu J, Cui G, Esmailian F, et al. Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation. Circulation 2004; 109: 3638. Aime-Sempe C, Folliguet T, Rucker-Martin C, et al. Myocardial cell death in fibrillating and dilated human right atria. J Coll Cardiol 1999; 34: 157786. Polontchouk L, Haefliger JA, Ebelt B, et al. Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. J Coll Cardiol 2001; 38: 88391. Mary-Rabine L, Albert A, Pham TD, et al. The relationship of human atrial cellular electrophysiology to clinical function and ultrastructure. Circ Res 1983; 52: 18899. van Berlo JH, de Voogt WG, van der Kooi AJ, et al. Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A C mutations portend a high risk of sudden death? J Mol Med 2005; 83: 7983. Pokharel S, van Geel PP, Sharma UC, et al. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2 3. Circulation 2004; 110: 312935. Sharma OP, Maheshwari A, Thaker K. Myocardial sarcoidosis. Chest 1993; 103: 2538. Maixent JM, Paganelli F, Scaglione J, et al. Antibodies against myosin in sera of patients with idiopathic paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol 1998; 9: 6127. Rocken C, Peters B, Juenemann G, et al. Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation. Circulation 2002; 106: 20917. Leone O, Boriani G, Chiappini B, et al. Amyloid deposition as a cause of atrial remodelling in persistent valvular atrial fibrillation. Eur Heart J 2004; 25: 123741. Levy S. Factors predisposing to the development of atrial fibrillation. Pacing Clin Electrophysiol 1997; 20: 26704. Barretto AC, Mady C, Nussbacher A, et al. Atrial fibrillation in endomyocardial fibrosis is a marker of worse prognosis. Int J Cardiol 1998; 67: 1925. Lee YA, Liang CS, Lee MA, et al. Local stress, not systemic factors, regulate gene expression of the cardiac renin-angiotensin system in vivo: a comprehensive study of all its components in the dog. Proc Natl Acad Sci U S A 1996; 93: 1103540. Goette A, Staack T, Rocken C, et al. Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation. J Coll Cardiol 2000; 35: 166977. Tsai CF, Tai CT, Hsieh MH, et al. Initiation of atrial fibrillation by ectopic beats originating from the superior vena cava: electrophysiological characteristics and results of radiofrequency ablation. Circulation 2000; 102: 6774. Weber KT. Fibrosis and hypertensive heart disease. Curr Opin Cardiol 2000; 15: 26472. Willems R, Sipido KR, Holemans P, et al. Different patterns of angiotensin II and atrial natriuretic peptide secretion in a sheep model of atrial fibrillation. J Cardiovasc Electrophysiol 2001; 12: 138792. Lendeckel U, Arndt M, Wrenger S, et al. Expression and activity of ectopeptidases in fibrillating human atria. J Mol Cell Cardiol 2001; 33: 127381. Cardin S, Li D, Thorin-Trescases N, et al. Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways. Cardiovasc Res 2003; 60: 31525. Kumagai K, Nakashima H, Urata H, et al. Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. J Coll Cardiol 2003; 41: 2197204. Goette A, Arndt M, Rocken C, et al. Regulation of angiotensin II receptor subtypes during atrial fibrillation in humans. Circulation 2000; 101: 267881 and kaon.
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Upcoming meetings following the February 2004 CPMP plenary meeting: The next CPMP Gene Therapy Expert Group Chairman K. Cichutek ; will be held at the EMEA on 26-27 February 2004. The next Ad Hoc Working Group on non ; -clinical comparability of Biotechnology products Chairman Dr P. Kurki ; will be held at the EMEA on 18 March 2004. The 102nd plenary meeting of the CPMP will be held from 23-25 March 2004. The next CPMP Organisational Matters meeting will be held on Monday 22 March 2004. The next Invented Name Review Group meeting is scheduled to take place on Monday 22 March 2004. An Introductory session for new CPMP Members including CPMP Members from the new EU Members States in view of the new mandate of the CPMP ; will be held at the EMEA on 5 May 2004. An Extraordinary Organisational CPMP meeting will be held at the EMEA on 6 May 2004. PROCEDURAL ANNOUNCEMENT Announcement in relation to new and on-going post-authorisation procedures with all or part of CPMP Opinion Annexes affected. Marketing Authorisation Holders are informed that as of now, the Annexes to centralised Marketing Authorisations will always be handled as one individual document per EU language throughout the life of the medicinal product. Thus, all on-going and new post-authorisation procedures to start in February March 2004, with affected Annexes to the Marketing Authorisations, will need to include the revised product information as a full set of Annexes i.e. Annex I, II, IIIA & IIIB1 ; in one Word document per language, even when not all Annexes are affected. Marketing Authorisation Holders are strongly advised to follow carefully the revised PostAuthorisation Guidance Document : emea .int htms human postguidance list ; and the QRD templates which provide clear information regarding specific requirements for format and submission timelines for all 22 languages. Regarding applications for post-authorisation procedures which are on-going or have already been submitted due to start in February 2004, Marketing Authorisation Holders are advised to liaise with the respective EMEA Product Team Leader and invirase.
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