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Consuming too much licorice can result in digestive disorders and possible highly elevated blood pressure, so it is not advisable to use natural or prescription licorice herbal or prescription medications if you have a heart problem or hypertension.
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Placental transfusion syndromes Placental and cord abnormality resulting in twin-to-twin or other transplacental transfusion Use additional code to indicate resultant condition in fetus or newborn: fetal blood loss 772.0 ; polycythemia neonatorum 776.4 ; 762.4 762.5 Prolapsed cord Cord presentation Other compression of umbilical cord Cord around neck Entanglement of cord Knot in cord Torsion of cord Other and unspecified conditions of umbilical cord Short cord Thrombosis of umbilical cord Varices of umbilical cord Velamentous insertion of umbilical cord Vasa previa infection of umbilical cord 771.4 ; single umbilical artery 747.5.
The present study showed significant differences between neointimal coverage of BMS versus SES three to six months after implantation. All BMS had complete neointimal coverage, whereas neointima covering of SES struts was more lucent and less complete. Furthermore, incomplete neointimal coverage was associated with thrombus formation that tended to be more common in SES than in BMS. Intravascular ultrasound IVUS ; studies showed that in-stent restenosis was secondary to neointimal hyperplasia. Earlier angioscopic studies showed that complete neointimal coverage was the rule in BMS 9 11 ; . The IVUS studies also showed that drug-eluting stents reduced instent restenosis by inhibiting neointimal hyperplasia. Furthermore, one previous IVUS study showed that nonpolymeric paclitaxel-eluting stents not only inhibited intimal hyperplasia, but also increased the neointimal-free length of the stents; the length of stent that was free of IVUSdetectable intimal hyperplasia measured 3.2 4.8 mm in placebo stents, 6.1 5.6 mm in low-dose stents, and 8.7 6.1 mm in high-dose stents p 0.0029 ; 13 ; . The current study extended these observations by showing that SES not only suppressed intimal hyperplasia, but also left a significant portion of the stent struts fully exposed and uncovered, similar to immediately after implantation. In the current study, the lack of neointimal strut coverage was associated with thrombus formation. One previous pathological study reported that impaired healing i.e., failure to form a complete neointimal layer over the stent struts ; extended the window during which stents were prone to thrombosis 7 ; , and VBT also inhibited neointimal growth. In patients treated with VBT, the lack of reendothelialization and late thrombosis were related, especially in the setting of new stent implantation 7, 14 ; . On the other hand, prolonged intensive antiplatelet therapy or reduced restenting when treating in-stent restenosis with VBT decreased the late stent thrombosis rate 8 ; . One earlier serial angioscopic study showed that intimal coverage of BMS proceeded gradually with subsequent neointimal remodeling shrinkage ; up to two years 11 ; . Similarly, in the current analysis the grade of neointimal coverage in BMS was related to the time from implantation to angioscopic follow-up even though all angioscopic studies were performed within six months. A recent case report on the pathology of SES-treated lesions showed that endothelial coverage was 80% complete after 16 months 15 ; . In the current study, neointimal coverage was unrelated to the time from DES implantation to angioscopic follow-up when all follow-up studies were performed within six.
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On 20 June, Minister of Trade and Industry Mauri Pekkarinen and Dag J. Opedal, CEO of Orkla ASA, opened Oy Panda Abs most recent investment, a new licorice line, in Vaajakoski, Finland. Pekkarinen and Opedal pointed out the importance of licorice and its contribution to Finland's food industry and Orkla's international food business. Panda holds a leading position on the Finnish licorice market and has a 28 % share of the Nordic licorice market.
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039 DO RENAL TRANSPLANT RECIPIENTS WITH STAGE 4 AND 5 CHRONIC KIDNEY DISEASE RECEIVE COMPARABLE CARE TO NON-TRANSPLANT PATIENTS? N. Hussain, V. Karthikeyan, J. Karpinski, G. Knoll, A. Akbari Division of Nephrology, Kidney Research Centre, The Ottawa Hospital, Ottawa, Ontario, Canada. Management of patients with renal insufficiency in a multidisciplinary chronic kidney disease clinic CKD-C ; has been shown to improve outcomes. It is not known whether renal transplant recipients RTR ; with CKD receive comparable care to those followed in a CKD-C. We compared complications related to renal dysfunction between RTR attending a transplant clinic and non-transplant patients with CKD attending a CKD-C. Eligible patients had MDRD GFR 30 ml min 1.73m2 KDOQI Stage 4 and 5 CKD ; . 72 RTR with Stage 4 or 5 CKD and 72 matched non-transplant patients were included in the analysis. The mean GFR was 22.9 ml min 1.73m2 for RTR and 21.3 ml min 1.73m2 for those in a CKD-C p 0.07 ; . RTR were younger 5114 yrs vs. 6816 yrs, p 0.0001 ; , had less diabetes 22% vs. 42%, p 0.012 ; and had less cardiovascular disease 18% vs. 46%, p 0.0001 ; compared to patients in CKD-C. The prevalence of hypertension was 90% in the RTR and 92% in the CKD-C. Thirty-one percent of RTR had significant anemia Hgb 110 g l ; compared to 19% of patients in CKD-C p 0.12 ; . However, only 41% of RTR with Hgb 110 g l were on EPO compared to 79% of patients in CKD-C p 0.027 ; . Other significant differences between RTR and patients in CKD-C are shown in the table. RTR had similar statin use 43% vs. 49%, p 0.5 ; , similar rocaltrol use 15% vs. 17%, p 0.82 ; and similar number of antihypertensives per patient 2.21.2 vs 2.31.2, p 0.59 ; compared to patients in CKD-C. The establishment of multidisciplinary CKD-C for RTR may help to improve outcomes for RTR returning to dialysis.
ELISE P. GOMEZ-SANCHEZ AND CELSO E. GOMEZ-SANCHEZ Research Service and Department of Internal Medicine, James A. Haley Veterans Hospital, and University of South Florida Health Science Center, Tampa, Florida 33612 Gomez-Sanchez, Elise P., and Celso E. GomezSanchez. Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone. Am. J. Physiol. 263 Endocrinol. Metub. 26 ; : El125El130, 1992.-The apparent mineralocorticoid excess syndrome of patients ingesting large amounts of licorice or its derivatives is thought to be caused by the antagonism by these compounds of the enzyme 1lp-hydroxysteroid dehydrogenase 1lfl-HSD ; . 1l -HSD inactivates cortisol and corticosterone, allowing the more abundantly produced glucocorticoids access to the mineralocorticoid receptor MR ; in the kidney, where they act as mineralocorticoids. We have found that the infusion of both glycyrrhizic acid, an active principle of licorice, and carbenoxolone, a synthetic analogue, into a lateral ventricle of the brain [intracerebroventricular icv ; ] of a rat, at a dose less than that which has an effect when infused subcutaneously, produces hypertension. Furthermore, the hypertension produced by the oral administration of carbenoxolone or glycyrrhizic acid is blocked by the icv administration of RU 28318, an MR antagonist, at a dose below that which has an effect on blood pressure when infused subcutaneously. While the oral administration caused saline polydipsia and polyuria typical of chronic systemic mineralocorticoid excess, the icv licorice derivatives produced hypertension without affecting saline appetite. Sensitizing the rats to mineralocorticoid hypertension by renal mass reduction and increasing salt consumption was not necessary for the production of hypertension. These findings provide additional evidence for a central role in blood pressure control by mineralocorticoids that is distinct from their renal effects. They also suggest that more is involved in licoriceinduced hypertension than only inhibition of II -HSD. hypertension; licorice; mineralcorticoids; RU 283 18; steroid 1Ifi-hydroxysteroid dehydrogenase and liothyronine.
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Diagnosis is very important to prevent morbidity and permanent sequels and also for the success of the treatment. In the light of these points, accurate, sensitive and prompt amino acid analysis in biological fluids is very important. Blood, urine, cerebrospinal fluid, vitreous fluid and amnion fluid are used for the diagnosis of disorders of amino acid metabolism. The analytical techniques for the measurement of amino acids can be investigated in two parts as screening tests and quantitative methods. Screening tests including Guthrie test, thin layer chromatography, paper chromatography, photometric methods and spot tests in the urine. In the recent years a world wide and important technique, that could screen many metabolic diseases in a single analytical step named tandem mass spectrometry has been used for this purpose. Among the tests those are used for the quantitative measurement of amino acids are capillary electrophoresis, gas-liquid chromatography, high pressure liquid chromatography, ion-exchange liquid chromatography amino acid analayzer ; and tandem mass spectrometry. High resolution nuclear magnetic resonance spectroscopy and molecular analysis are also used in amino acid measurements. One of the most recent and effective technic of those is tandem mass spectrometry. Tandem mass spectrometry is a very important analytical technique that could determine many metabolic diseases from one blood sample in a very short time in a single analytical step. Phenylketonuria, hyperphenylalaninemia, maple syrup urine disease, tyrosinemia type I and II, homocystinuria, hypermethioninemia are the disorders of amino acid metabolism those could be determined by tandem mass spectrometry. In addition to amino acid disorders fatty acid oxidation disorders, organic acidemias and urea cycle defects could also be determined by tandem mass spectrometry. In the newborn period, screening tests were begun by the screening of phenylketonuria which is a kind of bacterial inhibition test progressed by Robert Guthrie. Thin layer chromatography and paper chromatography are chromatographic methods those are used for the separation and determination of amino acids. In quantitative amino acid analysis with high pressure liquid chromatography the main steps of the method are the pre-column derivatization of the amino acids with phenylisothiocyanate, o-phthalaldehyde and other similar compounds, separation in reversed-phase column and detection with either ultraviolet or fluorescence detectors. In amino acid analayzer the main part of the system is ionexchange column, followed by gradient elution. Long period of investigation is a disadvantage for these methods. Amino acid levels in body fluids are influenced by a number of factors, such as age, physiological changes, nutritional status, diseases, medications and toxins. Also the factors such as collection time, transportation and keeping of the samples are very important. As a conclusion to gain success in the treatment and to prevent permanent sequels due to disorders of amino acid metabolism which makes up a great part of metabolic diseases, early diagnosis and treatment is highly important. Also the importance of the amino acid measurement.
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History: licorice is a woody-stemmed perennial plant found wild in southern and central europe and parts of asia that thrives in deep, rich, moisture-retentive, slightly-alkaline, sandy soil in full sun and lomotil.
In the early '90s, japanese scientists isolated certain compounds in licorice useful for skin care.
Fact is, when compared to the 3 million people who consumed licorice daily in the world, the number of individual cases of licorice induced hypokalemia in the literature is extremely rare and lomustine.
Expected there will be an increase in carbon emissions form the power generation sector over the next 15 years. A nuclear programme cannot provide short term emission reduction from the present levels, but it will ensure that emission increases are minimised and, in the long term, stabilised. The construction of each new nuclear plant will avoid the production of over 3 million tonnes of CO2 per year by negating the need for new CCGT plants. This figure would be even higher for clean coal or LNG fuelled plants It should however be noted that nuclear generation is not completely free.
When a patient who had experienced frequent arrhythmia was treated with Roasted Licorice Decoction, Holter ECG findings showed arrhythmia to be reduced to 10% or less. It is hoped that this mechanism can be clarified in further research and lortab.
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At my old job a co-worker told me that her daughter was born with severe heart problems because she was using licorice to help with morning sickness and lotronex.
Results and Discussion Primary Prostate Cancer Progression in the Absence of T-bet. To evaluate the role of T-bet in an autochthonous model of prostate cancer, TRAMP transgenic T-bet and T-bet animals were examined. When analyzed between 21 and 30 weeks of age, both T-bet-deficient and -sufficient TRAMP transgenic animals developed primary prostate cancers with comparable frequencies Table 1; Figs. 1 and 2 ; : 100% of TRAMP animals of both T-bet genotypes developed at least high-grade prostatic intraepithelial neoplasia, with 96% 25 of 26 ; of T-bet-deficient versus 91% 19 of 21 ; of T-bet-sufficient animals developing overt adenocarcinoma P was not significant ; . Interestingly, T-bet-deficient TRAMP animals developed somewhat higher grade adenocarcinomas than their T-bet-sufficient counterparts, although the magnitude of the difference was modest [92% 23 of 25 ; versus 72% 15 of 21 ; developing grades 2 or 3, respectively; P 0.023]. Whereas one of eight nontransgenic T-bet animals developed high-grade prostatic intraepithelial neoplasia, two of nine nontransgenic T-bet animals developed overt, low-grade adenocarcinoma P 0.088, comparing adenocarcinoma rates ; . However, overall tumor size, as judged by the size of the prostate, did not differ significantly between T-bet and T-bet counterparts 1.08 0.53 versus 1.19 0.67 cm, respectively; P was not significant ; . We therefore concluded that T-bet deficiency had little, if any, effect on primary tumor incidence and may have resulted in a modest increase in the rate of tumor progression. Increased Metastatic Disease in the Absence of T-bet. Distant metastases, particularly to the liver, salivary gland, and lung, occur spontaneously in TRAMP transgenic animals, presumably related to hematological dissemination 6, 7 ; . When examined for such lesions, T-bet-deficient animals consistently developed increased frequencies of metastatic disease; higher frequencies of animals developed metastases 3 of 21 T-bet versus 13 of 25 T-bet TRAMP animals; P 0.0033 ; , although the numbers of organs in individual animals with metastatic disease was not significantly affected 1.667 0.58 versus 1.62 0.87 organs in metastatic T-bet versus T-bet TRAMP animals, respectively; P was not significant ; . Nonetheless, when examined on a per-organ basis, tissues of T-bet-deficient animals clearly developed higher rates of metastasis when compared with their T-bet-sufficient counterparts 24% of 88 versus 6% of 79 organs examined, respectively; P 0.00083; Fig. 2C ; . Interestingly, metastasis was not observed in any of the nonTRAMP T-bet animals, but was seen in one of the non-TRAMP T-bet animals with low-grade prostatic adenocarcinoma n 8 and 9, respectively; P was not significant ; . We therefore concluded that T-bet indeed regulates cancer progression, but primarily by suppressing the rate at which the tumor progresses to metastatic capability. Mechanisms of Immunoregulation in the TRAMP Transgenic Model. Previous studies have demonstrated that effective antitumor responses in prostate cancer have been linked to type 1 helper T cells.
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