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75. Varis A, Puolakkainen P, Savolainen H, et al. DNA copy number profiling in esophageal Barrett adenocarcinoma: comparison with gastric adenocarcinoma and esophageal squamous cell carcinoma. Cancer Genet Cytogenet 2001; 127: 53 Walch AK, Zitzelsberger HF, Bruch J, et al. Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence. J Pathol 2000; 156: 555 van Dekken H, Geelen E, Dinjens WN, et al. Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal Barrett's ; and gastric cardia adenocarcinomas. Cancer Res 1999; 59: 748 Stocks SC, Pratt N, Sales M, et al. Chromosomal imbalances in gastric and esophageal adenocarcinoma: specific comparative genomic hybridizationdetected abnormalities segregate with junctional adenocarcinomas. Genes Chromosomes Cancer 2001; 32: 50 Riegman PH, Vissers KJ, Alers JC, et al. Genomic alterations in malignant transformation of Barrett's esophagus. Cancer Res 2001; 61: 3164 Gleeson CM, Sloan JM, McManus DT, et al. Comparison of p53 and DNA content abnormalities in adenocarcinoma of the oesophagus and gastric cardia. Br J Cancer 1998; 77: 277 Campomenosi P, Conio M, Bogliolo M, et al. p53 is frequently mutated in Barrett's metaplasia of the intestinal type. Cancer Epidemiol Biomarkers Prev 1996; 5: 559 Coggi G, Bosari S, Roncalli M, et al. p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations. Cancer 1997; 79: 425 Moore JH, Lesser EJ, Erdody DH, et al. Intestinal differentiation and p53 gene alterations in Barrett's esophagus and esophageal adenocarcinoma. Int J Cancer 1994; 56: 487 Weston AP, Banerjee SK, Sharma P, et al. p53 protein overexpression in low grade dysplasia LGD ; in Barrett's esophagus: immunohistochemical marker predictive of progression. J Gastroenterol 2001; 96: 1355 Bani-Hani K, Martin IG, Hardie LJ, et al. Prospective study of cyclin D1 overexpression in Barrett's esophagus: association with increased risk of adenocarcinoma. J Natl Cancer Inst 2000; 92: 1316 Doak SH, Jenkins GJS, Parry EM, et al. Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus. Gut 2003; 52: 623 Bian YS, Osterheld MC, Fontolliet C, Bosman FT, Benhattar J. p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus. Gastroenterology 2002; 122: 1113 Wong DJ, Paulson TG, Prevo LJ, et al. p16 INK4a lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium. Cancer Res 2001; 61: 8284 Fahmy M, Skacel M, Gramlich TL, et al. Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens. Mod Pathol 2004; 17: 588.
Incremental risk factor in additional to traditional cardiovascular prognostic factors.172 The Rotterdam Coronary Calcification Study, a large population-based study, showed a graded association between CAC score and stroke.78, 172 The American College of Cardiology ACC ; and American Heart Association AHA ; guidelines acknowledge the sensitivity of CAC to aid diagnosis of coronary atherosclerosis, with a similar predictive value to cardiac stress tests.173 Although EBCT may have specific utility in identifying asymptomatic patients at low to moderate risk, 174, 175 the ACC AHA guidelines currently do not recommend EBCT screening in patients owing to the paucity of data relating CAC and cardiovascular risk in the asymptomatic population.173 EBCT is, however, limited in that CAC scores may have little to do with luminal obstruction. Indeed, the precise relationship between CAC and cardiovascular disease risk remains unclear; moderate to severe CAC are consistently associated with abnormal stress-testing results, but minimal or no CAC does not preclude abnormal testing.176 Patients with little or no CAC can and do experience cardiac events. Furthermore, the reliability of EBCT is questionable; relative risks vary widely, and specificity has been disappointingly low. Another frequent criticism of EBCT as a measurement of CAC and progression of risk is the inherent subjectivity of the scan, even with use of the standardized Agatston score system. One evaluation of EBCT quantification of aortic valve calcification showed a low intra- and interobserver variability of approximately 4%, 177 with reliable interobserver variability. However, reproducibility between successive scans has been poor, ranging from 14% to 51% variability. 173 Furthermore, EBCT is not superior to other noninvasive diagnostic procedures in diagnosing CAD, including exercise stress tests, exercise echocardiography, or exercise perfusion imaging.173 Physicians should proceed with caution, especially when using this test to screen asymptomatic patients. The clinical significance of positive, and especially negative, results is unfortunately nebulous. At present, a better understanding of the relationship between EBCT and prognosis is needed before its widespread application is advisable.
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Were males with a mean age of 37.2 years. Seventy-three 96% ; of these individuals had immigrated to Canada a median of 48 months prior to presentation range 2-480 ; , with 22% immigrating more than 10 years before diagnosis. The most frequent regions of origin were Asia 38% ; , Africa 18% ; , South America 16% ; , and the Caribbean 12% ; . Three patients were born in Canada and had acquired their infection during travel to Bangladesh, Southeast Asia, and Mexico. The 76 patients presented clinically as follows: 32 patients 42% ; had gastrointestinal disturbances, most frequently epigastric pain, bloating or diarrhea; 17 22% ; had skin complaints, mostly urticaria or pruritis; three 4% ; had fever; and five 7% ; complained of pruritis ani. Nineteen patients 25% ; were asymptomatic. One patient had disseminated strongyloidiasis. The baseline laboratory findings are listed in Table 1. On baseline stool examination, 21 patients 27.6% ; had at least one other helminth identified; two patients 2.6% ; had three helminths detected. Sixty-nine patients 91% ; had a baseline eosinophil count recorded and of these, 57 82.6% ; had eosinophilia absolute eosinophil count 400 cells L ; with a mean eosinophil count of 923 cells L. Of the 51 patients with only S. stercoralis larvae identified, 42 82.4% ; had eosinophilia with a mean eosinophil count of 890 cells L. Seventyfour patients 97.4% ; had a baseline Strongyloides EIA performed at the CDC and in 70 94.6%, 95% confidence interval 92.0-97.2% ; it was reported as positive. Treatment history and follow-up of the eosinophil count and Strongyloides serology. The drug of choice for therapy of strongyloidiasis in Canada changed during the course of this study from thiabendazole to albendazole. Ivermectin was not readily available. Of the 75 patients treated one patient was lost to follow up ; , 36% were treated initially with thiabendazole; 36% with albendazole for three days and 28% with albendazole for seven days. Forty patients returned for followup; nine 22.5% ; received re-treatment with a second agent and one received a third agent. Of the 27 patients initially treated with thiabendazole, 11% were re-treated with albendazole. Of the 27 patients initially treated with albendazole for three days, 15% were re-treated with albendazole for seven days, and of the 21 patients initially treated with albendazole for seven days, 9.5% required re-treatment with albendazole for an additional seven days. The decision to re-treat with a second agent was based on repeat identification of S. stercoralis larvae in fecal specimens, or a persistently elevated eosinophil count and or unchanged serology. The change in eosinophil count after treatment is summarized in Table 2. In patients who had an eosinophil count determined within three months following initial therapy, 55% had a normal eosinophil count, compared with only 17% at baseline. In addition, there was a further decrease in those with eosinophilia at 3 to months 72% of treated.
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If any shall suggest, that some of the Enquiries here insisted upon as particularly those about the Letters of the Alphabet ; do seem too minute and trivial, for any prudent Man to bestow his serious thoughts and time about. Such Persons may know, that the discovery of the true nature and Cause of any the most minute thing, doth promote real Knowledge, and therefore cannot be unfit for any Mans endeauours, who is willing to contribute to the advancement of Learning. -- JOHN WILKINS, Towards a Real Character 1668 ; Clearly even the simple A.B.C. is a thing of mystery. Like all codes, it should not be trifled with, but it is to feared that in modern times it has not always been respected. -- STANLEY MORISON, On Type Faces 1923.
2301 5' cont'dl cont'd ; NOTE 3: 3269 Polyester resin kits have two components: a basic product Class 3, Group b ; or c , and an activator organic peroxide ; , each packed separately in an inner packaging. The organic peroxide shall be of types D, E or F, not requiring temperature regulation and restricted to 125 ml liquid and 500 g solid per inner packaging. The components may be placed in the same outer packaging, provided that they do not react dangerously with each other in the event of leakage. 6 * 3064 nitroglycerin solution in alcohol with more than 1% but not more than 5% nitroglycerin. NOTE: Special packing conditions are applicable for this substance see marginal 2303 see also Class 1, marginal 2101, 4 * , identification number 0144. 7 * B. b ; 1204 nitroqlvcerin solution in alcohol with not more than 1% nitroglycerin. Substances having a flashpoint below 23 * C and toxic. NOTE: 1. Toxic substances having a flashpoint of 23 'c above, and some substances listed by name in 1 to marginal 2601 are substances of Class 6.1. NOTE: 2. For toxicity criteria, see marginal 2600. 11 * Nitriles or isonitriles isocyanides ; : a ; 1093 acrvlonitrile. inhibited. 3079 methacrvlonitrile. inhibited. 3273 nitriles. flammable, toxic, n.o.s.: 2284 isobutvronitrile. 2378 2-dimethvlaminoacetonitrile. 2404 propionitrile. 2411 butvronitrile. 3273 nitriles. flammable, toxic, n.o.s!
References: 1. Sancar A., and Tang M.S. Nucleotide excision repair. Photochem. Photobiol. 1993; 57: 905-921. Eveno, E., Bourre, F., Quilliet, X., et al. Different removal of ultraviolet photoaducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases. Cancer Res. 1995; 55: 4325-4332. Hoeijmakers, J.H. Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies. Eur. J. Cancer. 1994; 13: 1912-1921. Hoeijmakers, J.H. and Bootsman, D. Molecular genetics of eukaryotic DNA excision repair. Cancer Cells. 1990; 2: 311-320. Svejstrup JQ, Vichi P, Egly JM. The multiple roles of transcription repair factor TFIIH. Trends Biochem Sci. 1996; 21 9 ; : 346-50. 6. Lehmann, A.R. The xeroderma pigmentosum group D XPD ; gene: one gene, two functions, three diseases. Genes Dev. 2001; 15: 1523. Bergmann, E. and Egly, J. Trichothiodystrophy, a transcription syndrome. Trends Genet. 2001; 17: 279286. Schaeffer, L., Monocollin, V., Roy, R., et al. The ERCC2 DNA repair protein is associated with the class II BTF2 TFIIH transcription factor. EMBO J. 1994; 13: 2388 Hoeijmakers JH, Egly JM, Vermeulen W. TFIIH: a key component in multiple DNA transactions. Curr Opin Genet Dev. 1996; 6 1 ; : 26-33. 10. Sung P, Bailly V, Weber C, Thompson LH, et al. Human xeroderma pigmentosum and thiamin.
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Delivered programmes. With digitalization, this fragmentation is expected to increase and give rise to television communities, with viewers tuning into thematic programming.While watching highlyspecialized channels, webviewers can look up material about the topic being presented or chat with other people connected to the site. More than 40 million people--about a quarter of all those online--already have software to access these sites and download sound and video from them onto their computers. The world's leading audiovisual portal, Broadcast recently taken over by Yahoo! ; , gets half a million visitors every day. What about the future? As television and the Web converge, will the familiar old TV set disappear? It seems unlikely, since the two means of communication are distinct--the Internet meets the needs of the individual, and television addresses a mass audience.They also have different publics-- the active Net-user and the passive TV viewer. So we can be fairly sure TV will stay TV, whatever kind of screen we shall use to watch it. There will always be people who want to lap up the programmes offered on their favourite channel. Mass TV will always have a role in broadcasting major events which bring a mass audience together, such as the funeral of Princess Diana or the World Cup football final. n.
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I note that the midwives both followed the agreed procedures in [the public hospital] for this sort of emergency situation. In my opinion these are appropriate procedures. 6. Are there any other issues raised by the supporting documents? As noted above, there are some aspects of the management of shoulder dystocia in this case that might be improved. There should be a standard set of protocols to follow when shoulder dystocia is detected and these should be based on the most recent evidence about best practice. The ALSO course appears to be suitable for this purpose. Since evidence from Britain shows that midwives more often manage shoulder dystocia than any other professional group Hope et al., 1998 ; it is important that all midwives receive this training." An independent obstetrician and gynaecologist, Dr Alastair Haslam, provided the following expert advice: ". CLINICAL STORY 3. [Mrs B] was under pregnancy care of [team] midwife [Ms D]. This describes a system of care known elsewhere as caseload ; where [the hospital] employed midwives care for patients, usually in teams of two. This allows for regular time off for the midwives, and the institution provides administrative and other support. In return for this midwives are paid a salary rather than making claims directly on the maternity benefit scheme. 4. [Mrs B] [.] was aged 34. This was her third pregnancy. In 1988 she had a term delivery of a girl and in 1990 a delivery at 37 weeks of another girl. Baby weights were recorded as 7lb 14 oz 3570 gm ; and 8 lb 2 3690 gm ; . 5. From the records supplied [Mrs B] appears to have had a normal pregnancy. She had two scans in the early part of her pregnancy, the first to check dates and the second a foetal anatomy screen in mid pregnancy. 6. An antenatal swab was done on 12.01.99 and this was positive for Group B streptococcus. On 21.01.99 at around 26 weeks gestation she had a polycose screen for diabetes and this was normal at 6.3 mmol L., the limit of normality being 7.8 mmol L. This test being negative makes diabetes unlikely although not impossible. 7. There was another observation by midwife [Ms F] on 16.03.99 that this was a `big baby'. 8. Midwife [Ms D] reports in a letter of 20.12.99 that she `considered the comment and on examination did not find [Mrs B's] baby to be so large as to require ultrasound scan or specialist review'.
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Active in the vapour phase To test the vapour phase activity of enilconazole, a small paper disk impregnated with enilconazole was placed inside the cover of an inverted agar plate 1 ; , allowing no direct contact between the enilconazole disk and the culture medium. Any inhibitory activity observed is entirely due to the gas phase. As a comparison, another enilconazole paper disk was placed directly on the culture medium of an inverted agar plate 2 ; . Here, the observed activity is due to diffusion. Both plates were inoculated with Aspergillus. After incubation, both plates showed a central area in the culture medium with total growth inhibition of the fungi and a secondary area where the mycelium had developed, but no spores were formed. Even in the absence of direct contact, the gas phase activity of enilconazole has a strong activity inhibiting mycelial growth and spore formation. A thousand times more active than thiabendazole Enilconazole is more than a thousand times more active against Aspergillus than thiabendazole. It is also more effective against dermatophytes. The growth of most fungi was completely inhibited at concentrations of 1 to mg l. It is even active against yeasts and, to some extent, against gram-positive bacteria and thiotepa.
2P D ; CHIPPERFIELD A.R. Naa + K ; co-transport in human red cells: kinetic interactions between external K and piretanide. C ; 53P CHIPPERFIELD A.R. & MANGAT D.S. Na + K ; Co-transport in human red cells increases with cell age. 67P COHEN J.B., GEMMELL H., HAYES P.A., SMITH F.W. & SOWOOD P.J. A comparison of magnetic resonance imaging, ultrasound and skinfold caliper techniques to measure subcutaneous fat thickness in humans. C ; 61P COLE J.D., HERBAUT A.G. & SEDGWICK E.M. Cutaneous vasoconstrictor reflexes following unilateral cortical lesions in man. C ; 63P COLOMO F., LOMBARDI V. & PIAZZESI G. A velocity-dependent shortening depression in the development of the force-velocity relation in frog muscle fibres. 227 CRAMB G. see AITON J.F., CRAMB G. & RUGG E.L. Rapid degradation of 1251-atrial natriuretic factor by isolated rat and rabbit ventricular myocytes. 72P CROOKS J. & MORRISON J.D. Synaptogenesis in the inner plexiform layer of area centralis of kitten retina. 74P CROSS Brenda A., LEAVER Kathryn D., SEMPLE S.J.G. & STIDWILL R.P. The effect of small changes in arterial carbon dioxide tension on carotid chemoreceptor activity in the cat. 415 CUMMIN Andrew R.C., IWAYE Vincent I., JACOBI Margaret S., MEHTA Nawser, PATIL Chandu P. & SAUNDERS Kenneth B. Immediate ventilatory response to sudden changes in venous return in humans. 45 CUNDEN Frances & SINGH J. Acetylcholine-evoked potassium, calcium and magnesium transport in the isolated rat lacrimal glands. C ; 56P CUNNINGHAM S.A. & NICHOLLS D.G. Chronic in vivo noradrenaline infusion mimics cold adaptation in brown adipose tissue in the guinea pig. C ; 49P DEITMER Joachim W. Voltage dependence of two inward currents carried by calcium and barium in the ciliate Stylonychia mytilus. 551 DINGLEDINE Raymond, HYNES Mary A. & KING Gregory L. Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice. 175 DODT H.U. & MISGELD U. Muscarinic slow excitation and muscarinic inhibition of synaptic transmission in the rat neostriatum. 593 DONCKIER J. see ANDERSON J.V., DONCKIER J. & BLOOM S.R. Evidence supporting the hypothesis that atrial natriuretic peptide ANP ; is a natriuretic hormone in normal man. C ; 46P DRAKE-HOLLAND A.J. & WIDDICOMBE J.G. Haemoglobin substitution and oxygen carrying capacity in the chloralose anaesthetized dog. C ; 39P DYBALL R.E.J. & LENG G. Regulation of the milk ejection reflex in the rat. 239 EASTWOOD J.C. & FLITNEY F.W. Laser spectroscopic studies of actin-myosin interaction in isolated active frog's muscle: wavelength dependence of transparency changes during stretch. C ; 28P.
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Stromectol administered as a single dose of 200 µ g kg for 1 day was as efficacious as thiabendazole administered at 25 mg kg d and thiothixene.
Product Presentation Category PoM Pharmacy sales Pharmacy NHS blacklisted Prescribable on the NHS NHS cost pack size ; MIMS May 2000 8.89, 10.83 ; Cost to purchase OTC MIMS May 2000 Comments.
Tolerances have been established 40 cfr 18 242 ; for the residues of thiabendazole in or on variety of raw agricultural commodities and thorazine.
An identifier for the attribute This information is used to filter out events so that each EditPart only processes changes that are unique to properties of that particular part. Processing of more generic changes, for instance a change to a part's size or location, should be delegated to the superclasses implementations of notifyChanged ; . Note that the notification mechanism provided by EMF is very thorough, so that a change to any attribute will result in a notification event. This means that a more complicated model operation, in which several attributes are manipulated, results in a large number of notification events. Ideally the EditPart's implementation will filter these events accordingly so that the visual representation is maintained accurately while events that do not require a change to the visual representation are ignored. Remember that a single EditPart may be responsible for the representation of more than one object in the underlying model. In our sample application this is the case with WorkflowNodeEditParts, which represent a WorkflowNode with some number of Ports. In our model the action of adding or removing a connection is something that happens to ports, not the WorkflowNode to which it is attached. Therefore our WorkflowNodeEditPart needs to perform some additional registration to make itself a listener on its WorkflowNode's ports. Otherwise it will not be notified of connection changes to its ports. This is done in the notifyChanged ; method of the WorkflowNodeEditPart, which is a base class for all the EditParts in our sample application that support connections. When a port is added to any WorkflowNode model element, the WorkflowNodeEditPart adds itself as a listener on the new port.
Anilazine * Dyrene benomyl Benex Benlate Tersan 1991 cycloheximide * naramycin dodine Carpene Curitan Melprex Venturol etridiazole Aaterra Ethazol Koban Pansoil Terrazole Truban iprodione Glycophene Rovral metalaxyl Ridomil Subdue thiabendazole Apl-Luster Arbotect Mertect Tecto Thibenzole triadimefon Amiral Bayleton triforine Denarin Funginex Saprol * Discontinued in the U.S and tiagabine
Placebo and albendazole: epigastric pain, dizziness, headache, diarrhea, itching, vomiting No significant differences Placebo and observed albendazole: epigastric pain, headache, dizziness, itching with both groups Diarrhea and vomiting in albendazole group 37 individuals ; Cure rate for mebendazole Mebendazole and 6 d ; : levamisole groups: Hookworm 80.6 abdominal Roundworm 95.5 discomfort 3 or 4 Whipworm 85.7 individuals ; Cure rate for oxantel-pyrantel 1 of the levamisole pamoate 3 d ; : groups: mild Hookworm 82.0 epileptic symptoms Roundworm 97.7 1 individual ; Whipworm 79.2 Diarrhea Cure rate: Flubendazole: brief mild Whipworm, 89 for headache flubendazole and 94 for 1 individual ; , mebendazole intermittent abdominal cramps 1 individual ; No significant differences No adverse events Cure rate: Hookworm 100 Roundworm 96 Whipworm 98 Vomiting, nausea, headache, abdominal pain reported more in thiabendazole and bepheniumhydroxinapthoate vs levamisole and thiabendazole.
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7. Katz R, Hood WR. Topical thiabendazole for creeping eruption. Arch Dermatol 1966; 94: 643645. Jones SK, Reynolds NJ, Oliwiecki S, Harman RRM. Oral albendazole for the treatment of cutaneous larva migrans. Br J Dermatol 1990; 122: 99101. Van den Enden E, Stevens A, Van Gompel A. Treatment of cutaneous larva migrans. N Engl J Med 1998; 339: 12461247. Caumes E, Carriere J, Datry A, Danis M, Gentilini M. A randomized trial of ivermectin versus albendazole for the treatment of cutaneous larva migrans. J Trop Med Hyg 1993; 49: 641644. ADDRESS: Sastry Prayaga, MD, State University of New York Upstate Medical University, 750 E. Adams Street, CWB, Rm. 322, Syracuse, NY 13210; e-mail sprayaga pol and timolol.
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Dr. William J. McIlroy left ; , national medical advisor for the MS Society of Canada, and Dr. Samuel Ludwin, Chair, Scientific Advisory Panel.
Inclusion COPD Age 40 as of 2003 mos of continuous plan enrollment Chronic bronchitis ICD9: 491.x and 490.x ; Emphysema ICD9: 492.x, and 518.x ; Bronchiectasis ICD9: 494.x ; or other chronic airway obstructions not otherwise defined ICD9: 496.x ; Ipratropium and albuterol therapy for a minimum of 12 months IAC or DSA ; Exclusion Human immunodeficiency virus ICD9: 042.x0.44x ; or history of Diagnosis of neoplasms ICD9: 140.x239.x ; within 3 months of the end of the analysis Asthma ICD9 493.x ; without concurrent diagnosis of COPD ICD9: 490.x, 491.x, 492.x, or 518.x ; Extrinsic allergic alveolitis ICD9 495.x and ting.
Table 19.1. Landmarks in ascariasis BC Adult worms have been known since ancient times and various anthelmintics have been employed c.170 AD Galen knew that adult worms normally inhabited the upper small intestine 1683 Tyson described the anatomy of the worm and clearly distinguished it from the earthworm. He discovered the eggs 1849 Gros found that eggs took several months to embryonate 1856 Ransom showed that ascariasis could be diagnosed by finding eggs in the faeces 1862 Davaine showed that eggs remained viable for up to five years 1862 Davaine discovered that when embryonated eggs were fed to rats, larvae were liberated in the small intestine then were passed in the faeces 1879 Grassi swallowed embryonated eggs and claimed to find evidence of a patent infection 22 days later 1886 Calandruccio gave 150 eggs to a boy and recovered 143 worms after anthelmintic administration three months later 1916 Stewart found that larvae liberated from eggs in the intestines of rats underwent systemic migration through the lungs then returned to the gut 1922 Koino infected himself with 2, 000 eggs, recovered larvae from his sputum several days after infection, then recovered 667 immature worms from his intestines after anthelmintic administration 50 days after infection 1949 Fayard reported that piperazine was a useful treatment 1958 Bephenium was shown by Goodwin and colleagues to be useful for treatment 1962 Bui Quoc Hong and co-workers showed that thiabendazole was an effective treatment 1966 Tetramisole was demonstrated by Do Nascimento and colleagues to be efficacious 1969 Thienpont and colleagues showed that levamisole was even more effective than tetramisole 1970 Amato Neto and co-workers indicated that pyrantel was active 1973 Mebendazole was shown by a number of investigators to be useful in ascariasis and thiamin.
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