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48. Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4 + ; CD25 + ; immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med. 2002; 196: 401-406. Levings MK, Sangregorio R, Roncarolo MG. Human cd25 + ; cd4 + ; t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001; 193: 1295-1302. Zhou J, Carr RI, Liwski RS, Stadnyk AW, Lee TD. Oral exposure to alloantigen generates intragraft CD8 + regulatory cells. J Immunol. 2001; 167: 107-113. Gilliet M, Liu YJ. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med. 2002; 195: 695-704. Zhang ZX, Yang L, Young KJ, DuTemple B, Zhang L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med. 2000; 6: 782-789. Zhang ZX, Young K, Zhang L. CD3 + CD4-CD8- alphabeta-TCR + T cell as immune regulatory cell. J Mol Med. 2001; 79: 419-427. Zeng D, Lewis D, Dejbakhsh-Jones S, Lan F, Garcia-Ojeda M, Sibley R, Strober S. Bone marrow NK1.1 - ; and NK1.1 + ; T cells reciprocally regulate acute graft versus host disease. J Exp Med. 1999; 189: 1073-1081. Seino KI, Fukao K, Muramoto K, Yanagisawa K, Takada Y, Kakuta S, Iwakura Y, Van Kaer L, Takeda K, Nakayama T, Taniguchi M, Bashuda H, Yagita H, Okumura K. Requirement for natural killer T NKT ; cells in the induction of allograft tolerance. Proc Natl Acad Sci U S A. 2001; 98: 2577-2581.
Of monoamines by a fluorescence method. Ada Physiol Scand 1962.
Treatment given to these patients after diagnosis of their renal lesion is summarized in Table 5. Renal function improved in seven of the nine patients who presented with impaired renal function. Two patients 3 and 5 ; were dialysis-dependent at the time of presentation. Both recovered renal function and.
From the Institute of Hematology and Medical Oncology "L.&A. Seragnoli, " ` University of Bologna, Italy; the Hematology Service "S. Maria Nuova" Hospital, Reggio Emilia, Italy; the Hematology Service "S. Salvatore" Hospital, Pesaro, Italy; and the Chair of Hematology, University Hospital, Udine, Italy. Submitted February 10, 2003; accepted April 18, 2003. Prepublished online as Blood First Edition Paper, April 24, 2003; DOI 10.1182 blood-2003-02-0440. Supported by the University of Bologna funds for selected topics.
Accounting, and an M.B.A. in Strategy and Marketing, all from McGill University. In addition, Ms. Sakhia is a Canadian-designated activities. Before Pharmacia, Mr. Nawacki worked for the Pillsbury Company in brand financial management, and prior to this Mr. Freeman joined Paladin in 2000 as Group Product Director, Urology and was promoted to Director of Marketing in 2003.
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26 Eichinger MR, Walker BR. Nitric oxide and cGMP do not affect fluid flux in isolated rat lungs. J Appl Physiol 1996; 80: 69 Fratacci MD, Frostell CG, Chen TY, et al. Inhaled nitric oxide: a selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology 1991; 75: 990 Raikar GV, Hisamochi K, Raikar BL, et al. Nitric oxide inhibition attenuates systemic hypotension produced by protamine. Thorac Cardiovasc Surg 1996; 111: 1240 Cable DG, Sorajja P, Oeltjen MR, et al. Different effects of protamine on canine coronary microvessel and conductance arteries: evidence of hyperpolarizing factor release. Surgery 1999; 126: 835 Yiu P, Robin J, Pattison C. Reversal of refractory hypotension with single-dose methylene blue after coronary artery bypass surgery. Thorac Cardiovasc Surg 1999; 118: 195196 Andrade JCS, Batista Filho ML, Evora PRB, et al. Methylene blue administration in the treatment of the vasoplegic syndrome after cardiac surgery. Rev Bras Circ Cardiovasc 1996; 11: 107114 Evora PRB, Ribeiro PJF, Andrade JCS. Methylene blue administration in SIRS after cardiac operations [letter]. Ann Thorac Surg 1997; 63: 112113 Evora PRB. Should methylene blue be the drug of choice to treat vasoplegias caused by cardiopulmonary bypass and anaphylactic shock [letter]? Thorac Cardiovasc Surg 2000; 119: 633 Evora PRB, Roselino CH, Schiavetto PM. Methylene blue in anaphylactic shock [letter]. Ann Emerg Med 1997; 30: 240.
11 . Have you ever had any difficult extractions in the past? 12.Have you ever had any prolonged bleeding following extractions? 13. Have you had any orthodontic treatment ? 14. Do you wear dentures or partials? Ifyes, date of placement 15. Have you ever received oral hygiene instructions regarding the care of your teeth and gums? 16. Do you lihe your smile? and ethionamide.
Anticipation Elan Pharm. Inc. v. Mayo Found. for Medical Educ. and Research, 64 U.S.P.Q.2d 1292 Fed. Cir. 2002 ; . The Federal Circuit reversed the district court's judgment of invalidity based John C. Gatz on anticipation. Although a prior art patent described known procedures for making a transgenic animal, it did not describe every element of the claims and did not teach, other than by trial and error and hope, the production of a transgenic mouse having detectable ATFbetaAPP in brain homogenate. The Federal Circuit found that a general recitation of known procedures, none of which were carried out by the prior inventor, did not defeat the novelty of the claimed transgenic mouse. One of the elements of the appealed claims required the processing of human APP polypeptide having the Swedish mutation to form detectable ATF-betaAPP in the transgenic mouse's brain. The prior art patent did not mention producing detectable ATF-betaAPP. The Federal Circuit concluded that the prior art patent did not inherently show this limitation because no evidence existed that the formation and detection of ATF-betaAPP with the Swedish mutation in a transgenic mouse's brain was known to those of ordinary skill in the field of the invention. Thus, the Federal Circuit remanded for further proceedings based on its conclusion that the claims were not anticipated by the prior art patent. Judge Dyk dissented, concluding that the district court properly found the claims at issue invalid as inherently anticipated by the prior art patent. Judge Dyk stated that the majority erred in not using the inventor's own disclosure under Section 102 as the source of proof of anticipation by inherent disclosure. Judge Dyk indicated that the law allows the party raising the issue of inherency to fill in gaps in the disclosure using any source, including the inventor's own disclosure. Board of Patent Appeals and Interferences' Procedure In Re McDaniel, 63 U.S.P.Q.2d 1462 Fed. Cir. 2002 ; . The Board of Patent Appeals and Interferences Board ; , for.
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Nostudies ere w conducted U hildren in Adverse reactions froma trialin Indonesia children netotwelve in o yearsfage summarized o are inTABLE Nosevere 2~ orunusual effects observed. side were and ethosuximide.
JPET #90860 Punzi JS, Duax WL, Strong P, Griffin JF, Flocco MM, Zacharias DE, Carrell HL, Tew KD and Glusker JP 1992 ; Molecular conformation of estramustine and two analogues. Mol Pharmacol 41: 569-576. Rosenthal MA, Gruber ML, Glass J, Nirenberg A, Finlay J, Hochster H and Muggia FM 2000 ; Phase II study of combination taxol and estramustine phosphate in the treatment of recurrent glioblastoma multiforme. J Neurooncol 47: 59-63. Sjodin A, Guo D, Hofer PA, Henriksson R and Hedman H 2003 ; Mammaglobin in normal human sweat glands and human sweat gland tumors. J Invest Dermatol 121: 428-429. Sjodin A, Guo D, Lund-Johansen M, Krossnes BK, Lilleng P, Henriksson R and Hedman H 2005 ; Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas. Acta Neuropathol Berl ; 109: 381-386. Speicher LA, Barone L and Tew KD 1992 ; Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines. Cancer Res 52: 4433-4440. Speicher LA, Laing N, Barone LR, Robbins JD, Seamon KB and Tew KD 1994 ; Interaction of an estramustine photoaffinity analogue with cytoskeletal proteins in prostate carcinoma cells. Mol Pharmacol 46: 866-872. Stearns ME, Jenkins DP and Tew KD 1985 ; Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets. Proc Natl Acad Sci U S A 82: 8483-8487. Vulevic B, Chen Z, Boyd JT, Davis W, Jr., Walsh ES, Belinsky MG and Tew KD 2001 ; Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, subfamily A, transporter 2 ABCA2 ; . Cancer Res 61: 3339-3347.
49 ; Cunningham D, Pyrhonen S, James RD, Punt CJ, Hickish TF, Heikkila R, et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998; 352: 14138. ; Thongprasert S, Sanguanmitra P, Juthapan W, Clinch J. Relationship between quality of life and clinical outcomes in advanced non-small cell lung cancer: best supportive care BSC ; versus BSC plus chemotherapy. Lung Cancer 1999; 24: 1724. ; Ganz PA, Figlin RA, Haskell CM, La Soto N, Siau J. Supportive care versus supportive care and combination chemotherapy in metastatic nonsmall cell lung cancer. Does chemotherapy make a difference? Cancer 1989; 63: 12718. ; Woods RL, Williams CJ, Levi J, Page J, Bell D, Byrne M, et al. A randomised trial of cisplatin and vindesine versus supportive care only in advanced non-small cell lung cancer. Br J Cancer 1990; 61: 60811. ; Jacobsen MB, Hanssen LE. Clinical effects of octreotide compared to placebo in patients with gastrointestinal neuroendocrine tumors. Report on a double-blind, randomized trial. J Intern Med 1995; 237: 26975. ; de Haes JC, van Knippenberg FC, Neijt JP. Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br J Cancer 1990; 62: 10348. ; Goodchild ME, Duncan-Jones P. Chronicity and the General Health Questionnaire. Br J Psychiatry 1985; 146: 5561. ; Glimelius B, Ekstrom K, Hoffman K, Grof W, Sjoden PO, Haglund U, et al. Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann Oncol 1997; 8: 1638. ; Manesis EK, Giannoulis G, Zoumboulis P, Vafiadou I, Hadziyannis SJ. Treatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: a randomized, controlled trial. Hepatology 1995; 21: 153542. ; Selawry O, Krant M, Scotto J, Kazam E, Schneiderman M, Olson K, et al. Methotrexate compared with placebo in lung cancer. Cancer 1977; 40: 48. ; Castells A, Bruix J, Bru C, Ayuso C, Roca M, Boix L, et al. Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients. Gastroenterology 1995; 109: 91722. ; Goldberg RM, Moertel CG, Wieand HS, Krook JE, Schitt AJ, Veeder MM, et al. A phase III evaluation of a somatostatin analogue octreotide ; in the treatment of patients with asymptomatic advanced colon carcinoma. Cancer 1995; 76: 9616. ; Gleave ME, Elhilali M, Fradet Y, Davis I, Venner P, Saad F, et al. Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma. N Engl J Med 1998; 338: 126571. ; Iversen P, Rasmussen F, Asmussen C, Christensen IB, Eickhoff J, Klarskor P, et al. Estramustine phosphate versus placebo as second line treatment after orchiectomy in patients with metastatic prostate cancer: DAPROCA Study 9002. J Urol 1997; 157: 92934. ; Grimaldi C, Bleiberg H, Gay F, Messner M, Rougier P, Kok TC, et al. Evaluation of antiandrogen therapy in unresectable hepatocellular carcinoma: results of a European Organization for Research and Treatment of Cancer multicentric double-blind trial. J Clin Oncol 1998; 16: 4117. ; Cellerino R, Tummarello D, Guidi F, Pierpaolo I, Raspugli M, Biscottini B, et al. A randomized trial of alternating chemotherapy versus best supportive care in advanced non-small-cell lung cancer. J Clin Oncol 1991; 9: 145361. ; Lai CL, Lau JY, Wu PC, Ngan H, Chung HT, Mitchell SJ, et al. Recombinant interferon in inoperable hepatocellular carcinoma: a randomized controlled trial. Hepatology 1993; 17: 38994. ; Kaasa S, Lund E, Thorud E, Hatlevoll R, Hst H. Symptomatic treatment versus combination chemotherapy for patients with extensive non-small cell lung cancer. Cancer 1991; 67: 24437. ; Oliver RT. Are cytokine responses in renal cell cancer the product of placebo effect of treatment or true biotherapy? What trials are needed now? Br J Cancer 1998; 77: 131820. ; Moertel CG, Hanley JA. The effect of measuring error on the results of therapeutic trials in advanced cancer. Cancer 1976; 38: 38894. ; Warr D, MacKinney S, Tannock I. Influence of measurement error on assessment of response to anticancer chemotherapy: proposal for new criteria of tumor response. J Clin Oncol 1984; 2: 10406 and etidronate.
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Estramustine phosphate is a combination of estradiol with nornitrogen mustard. The precise mechanism of action of estramustine is unknown. Unlike other alkylating agents, estramustine does not directly damage DNA.
Statistical analysis. Hormone measurements were log-transformed prior to analyses. For differences between groups, data was compared by ANOVA with a Scheffe correction for multiple comparisons. For within group comparisons relative to baseline, paired T-tests with a Bonferroni correction for multiple comparisons effective 0.01 ; were performed on the logtransformed values. For all comparisons, a P value 0.05 was considered statistically significant. Statistical analyses were performed using STATA College Park, TX, USA and etodolac.
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1. Yagoda A. Non-hormonal cytotoxic agents in the treatment of prostatic adenocarcinoma. Cancer 1973; 32: 1131 Yagoda A, Watson RC, Natale RB, et al. A critical analysis of response criteria in patients with prostatic cancer treated with cis-diamminedichloride platinum II. Cancer 1979; 44: 1553 Scher HI, Mazumdar M, Kelly WK. Clinical trials in relapsed prostate cancer: defining the target. J Natl Cancer Inst 1996; 88: 1623 Dawson NA, McLeod DG. The assessment of treatment outcomes in metastatic prostate cancer: changing endpoints. Eur J Cancer 1997; 33: 560 Scher HI, Eisenberger M, D' mico AV, et al. Eligibility A and outcomes reporting guidelines for clinical trials for patients in the state of a rising prostate-specific antigen: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol 2004; 22: 537 Bubley GJ, Carducci M, Dahut W, et al. Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the PSA Working Group. J Clin Oncol 1999; 17: 1 Scher HI, Kelly WK, Zhang Z-F, et al. Post-therapy serum prostate specific antigen level and survival in patients with androgen-independent prostate cancer. J Natl Cancer Inst 1999; 91: 244 D' mico AV, Moul J, Carroll PR, Sun L, Lubeck D, A Chen MH. Prostate specific antigen doubling time as a surrogate end point for prostate cancer specific mortality following radical prostatectomy or radiation therapy. J Urol 2004; 172: S42 6; discussion S6 7. 9. mico AV, Moul JW, Carroll PR, Sun L, Lubeck D, A Chen MH. Surrogate end point for prostate cancerspecific mortality after radical prostatectomy or radiation therapy. J Natl Cancer Inst 2003; 95: 1376 Kelloff GJ, Coffey DS, Chabner BA, et al. Prostatespecific antigen doubling time as a surrogate marker for evaluation of oncologic drugs to treat prostate cancer. Clin Cancer Res 2004; 10: 3927 Heicappell R, Muller-Mattheis V, Reinhardt M, et al. Staging of pelvic lymph nodes in neoplasms of the bladder and prostate by positron emission tomography with 2-[ 18 ; F]-2-deoxy-D-glucose. Eur Urol 1999; 36: 582 Hofer C, Laubenbacher C, BlockT, Breul J, Hartung R, Schwaiger M. Fluorine-18-fluorodeoxyglucose positron emission tomography is useless for the detection of local recurrence after radical prostatectomy. Eur Urol 1999; 36: 31 Liu IJ, Zafar MB, Lai YH, Segall GM, Terris MK. Fluorodeoxyglucose positron emission tomography studies in diagnosis and staging of clinically organconfined prostate cancer. Urology 2001 ; 57: 108 11. Sanz G, Robles JE, Gimenez M, et al. Positron emission tomography with 18fluorine-labelled deoxyglucose : utility in localized and advanced prostate cancer. BJU Int 1999; 84: 1028 Shreve PD, Grossman HB, Gross MD, Wahl RL. Metastatic prostate cancer: initial findings of PETwith 2-deoxy-2[F-18]fluoro-D-glucose. Radiology 1996; 199: 751 Effert PJ, Bares R, Handt S, Wolff JM, Bull U, Jakse G. Metabolic imaging of untreated prostate cancer by positron emission tomography with18fluorine-labeled deoxyglucose. J Urol 1996; 155: 994 Morris MJ, Akhurst T, Osman I, et al. Fluorinated deoxyglucose positron emission tomography imaging in progressive metastatic prostate cancer. Urology 2002; 59: 913 Hamacher K, Coenen HH, Stocklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 1986; 27: 235 Scher HI, Heller G. Clinical states in prostate cancer: towards a dynamic model of disease progression. Urology 2000; 55: 323 Solit DB, Morris M, Slovin S, et al. Clinical experience with intravenous estramustine phosphate, paclitaxel, and carboplatin in patients with castrate, metastatic prostate adenocarcinoma. Cancer 2003; 98: 1842 Kelly WK, Curley T, Slovin S, et al. Paclitaxel, estramustine phosphate, and carboplatin in patients with advanced prostate cancer. J Clin Oncol 2001; 19: 44 Smaletz O, Galsky M, Scher HI, et al. Pilot study of epothilone B analog BMS-247550 ; and estramustine phosphate in patients with progressive metastatic prostate cancer following castration. Ann Oncol 2003; 14: 1518 Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205 Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351: 1502 Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004; 351: 1513.
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100 percent of estimated cost of the case; 120 percent of the ltc-drg per diem amount; the full ltc-drg payment; or a blend of an amount comparable to what would otherwise be paid under the ipps, computed as a per diem and capped at the full ipps drg comparable amount, and 120 percent of the ltc-drg per diem amount and exemestane.
Provides a substantial saving potential. A SAVE Study EECCAC ; showed that this potential was of the order of 50 % of current consumption. The rational approach A rational actor will take the following steps to improve energy-efficiency: Manage and benchmark his systems and their consumptions. This can be done by every building-owner using very little information but well located indicators. The pre-audit or inspection ; is usually carried out either as part of some other process such as a change of use, or within a maintenance operation ; or because the indicators reveal a problem. It typically requires one or two days work, usually by a professional, supplemented by existing records and "spot" measurements and allows the identification of easily identifiable faults and possible improvements The audit or detailed audit ; is necessarily carried out by a professional, typically to further investigate opportunities identified by the pre-audit. It produces quantative estimates of the costs and saving to be expected It can take from several days say 5 to 10 ; several months 1 to 6 ; long-term measurements are needed. If justified, investment in renovation or replacement of the system or components follows. Before a decision on investment is made, it may be necessary to obtain detailed quotations and make more detailed assessment of the likely savings. This we call an "investment grade audit". This rational approach is not common, especially in the case of AC. It is well known that in order to generate financial savings, industries and building occupants' investment priority is their "core business". However, spending money to improve "utilities" is often pre-judged to be less rewarding: a serious barrier to energy-efficiency. Clearly, from a business perspective, the financial criteria applied to investments in energy efficiency should be the same as those applied to other business investments. For many businesses, the loss of productivity that results from poor environmental conditions will be at least as financially important as energy costs. This aspect is not normally addressed by energy auditing, but could usefully be considered as part of a full audit. For air-conditioning in buildings, the lack of established procedures for assessing the potential for savings and the shortage of visible precedents by other businesses are additional hurdles. In comparison to industry, an additional difficulty with buildings is that there can be several persons with diverging interests: the building-owner s ; , the occupant s ; and the operator s ; of the technical installations. This is called the problem of "split incentives". Different motivations for different actors to carry out a pre-audit A building owner who is also the occupant and the operator of his building manages his energy consumption and monitors comfort level or total costs. The detection of a problem can lead to a pre-audit by an independent expert and estramustine.
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