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Labeled antibody in a nude mouse human breast cancer model. Others have used this combination successfully in breast and prostate cancers 134, 135 ; . In addition to the taxanes, other chemotherapeutic agents have been reported to enhance the activity of RIT when used at submaximal doses 136, 137 ; . As with any combination modality, numerous dosing and scheduling issues are involved in optimizing the therapy. Several reports have reviewed this process, particularly as it relates to the p53 status of a given cell line 138 140 ; . For example, starting with the SKOV-3 p53null cell line, Blumenthal et al. 140 ; examined 3 p53transfected cell lines that differed in their p53 mutation locus. They found considerable differences in each cell line's sensitivity to various drugs and to the drugRIT combination. Several combinations were found to be antagonistic, highlighting the difficulty that may be encountered in the future with certain chemotherapyRIT combinations as well as indicating ways in which prescreening of cancer biopsies could be used to optimize treatment planning 140 ; . The second approach, combining RIT with more conventional doses of drugs, rests on the assumption that RIT can enhance the chemotherapeutic regimen. However, this may prove difficult, because many conventional drugs are also myelosuppressive. Nevertheless, several reports in animal models have suggested promise for this approach 141146 ; . Initial results of feasibility trials have been reported for combining intraperitoneal RIT with 177Lu- or 90Y-labeled anti-TAG-72 CC49 and chemotherapy in regional therapy of ovarian cancer as well as for 90Y-labeled anti-CEA antibody combined with a continuous infusion treatment regimen of 5-FU in chemorefractive colorectal cancer 147 149 ; . Although each of these regimens has been tolerated, with hematologic toxicity being dose limiting, it is too early to assess whether these combination modalities significantly enhance the effects of RIT for any specific chemotherapy regimen. However, based on studies in ovarian cancer, the trend continues to favor the treatment of less advanced disease with these combinations
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Director General of the The ILO and UNAIDS "No single OPEC Fund, HE Dr. Y. delegations apprised the government or Seyyid Abdulai, conveyed international agency Fund of their respective concern about the HIV strategies, objectives, modes will, in isolation, AIDS epidemic and emof operation and activities be able to tackle phasized the Fund's firm in the areas of prevention, the problem, which intention to intensify its treatment and support transcends participation in the global structures at the national, national boundaries. fight against the disease. regional and international HIV AIDS . represents Dr. Abdulai acknowledged levels. an impediment to that no single government Although both ILO and sustainable socioor international agency UNAIDS are specialized economic development would, in isolation, be able agencies of the UN system, and poverty alleviation, their mandates and priorito tackle the problem, and requires a which transcends national ties in combating HIV concerted, long-term, boundaries. HIV AIDS, all AIDS are quite distinct. structured response parties agreed, represents UNAIDS was established by the international an impediment to sustainin 1996 as an inter-agency community as able socio-economic develalliance co-sponsored, on a whole. opment and poverty alle a voluntary basis, by seven viation, and requires a UN organizations UNIconcerted, long-term, structured reCEF, UNDP, UNFPA, UNESCO, WHO, sponse by the international communiUNDCP, and the World Bank ; . As the ty as a whole. leading advocate for worldwide action against HIV AIDS, the mission of UNAIDS is to catalyse, strengthen and orchestrate the efforts made by each of these UN bodies to prevent the spread of the pandemic and alleviate its devastating socio-economic and human impact. Established in 1919, the ILO's primary goal is to provide opportunities for women and men to obtain decent and productive work conditions of freedom, equity, security, and human dignity. Since HIV AIDS predominantly takes its toll on people in the most productive age groups 15-45 ; , it affects men and women in all types of work and employment, paid or unpaid, in both the public and the private sectors. Although ILO is not part of the UNAIDS interagency alliance, it signed a protocol with UNAIDS in June 2000 to deal with HIV AIDS in the workplace. The meetings at OPEC Fund headquarters provided ample scope for questions on both sides of the table, and generated vivid discussions about a wide OPEC Fund Director-General HE Dr. Y. Seyyid Abdulai right ; with his guests from UNAIDS, Dr. Olavi Elo, range of possibilities for joining forces and Director of Social Mobilization and Information center ; , and Mr. Ross Noble, Senior Advisor, External working together at all levels. s Relations, at the meeting.
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Ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db pubmed&dopt Abstract&list uids 1125766 8 Kortmann BB, Sonke GS, Wijkstra H, Nordling J, Kallestrup E, Holm NR, De la Rosette JJ. Intra- and Inter-investigator variation in the analysis of pressure-flow studies in men with lower urinary tract symptoms. Neurourol Urodyn 2000; 19: 221-32. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 10797579&dopt Abstra ct Rowan D, James ED, Kramer AE, Sterling AM, Suhel PF. Urodynamic equipment: technical aspects. Produced by the International Continence Society Working Party on Urodynamic Equipment. J. Med Eng Technol 1987; 11: 57-64. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 2956425&dopt Abstract Schafer W. A new concept for simple but specific grading of bladder outflow condition independent from detrusor function. J Urol 1993; 149: 574-577. Abrams P, Griffiths DJ. The assessment of prostatic obstruction from urodynamic measurements and from residual urine. Br J Urol 1979; 51: 129-134. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 465971&dopt Abstract Rollema HJ, van Mastrigt R. Improved indication and follow-up in transurethral resection of the prostate using the computer program CLIM: a prospective study. J Urol 1992; 148: 111-116. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 1377287&dopt Abstract Griffiths D, Hofner K, van Mastrigt R, Rollema HJ, Spangberg A, Gleason D. Standardization of terminology of lower urinary tract function: pressure-flow studies of voiding, urethral resistance and urethral obstruction. Internation Continence Society Subcommittee on Standardization of Terminology of Pressure-Flow Studies. Neurourol Urodyn 1997; 16: 1-18. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 9021786&dopt Abstract Neal DE, Styles RA, Powell PH, Thong J, Ramsden PD. Relationship between voiding pressure, symptoms and urodynamic findings in 253 men undergoing prostatectomy. Br J Urol 1987; 60: 554-559. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 3427341&dopt Abstract Neal DE, Ramsden PD, Sharples L, Smith A, Powell PH, Styles RA, Webb RJ. Outcome of elective prostatectomy. BMJ 1989; 299: 762-767. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 2508914&dopt Abstract Abrams PH, Farrar DJ, Turn-Warwick RT, Whiteside CG, Feneley RC. The results of prostatectomy: a symptomatic und urodynamic analysis of 152 patients. J Urol 1979; 121: 640-642. : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 86617&dopt Abstract Jensen KME. Clinical evaluation of routine urodynamic investigations in prostatism. Neurourol Urodyn 1989; 8: 545-578. Robertson AS, Griffiths C, Neal DE. Conventional urodynamics and ambulatory monitoring in the definition and management of bladder outflow obstruction. J Urol 1996; 155: : ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&list uids 8558647&dopt Abstract Langen PH, Schafer W, Jakse G. Conventional assessment in patients undergoing transurethral resection of the prostate: a prospective study. In: Benign Prostatic Hyperplasia: Conservative and Operative Management. Jakse G, et al. eds ; . SpringerVerlag: New York, 1992, 75-84.
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The immune systems of bony fish is considered to be equivalent to the immune system of higher vertebrates, but the genes involved show high extent of sequence divergence, even between related fish species. Gene duplication followed by positive selection is typical in several gene families involved in immune responses. Divergence of these immune genes may lead to additional layers of functional redundancy or to acquisition of novel functions, both of which conceivably help the host cope more effectively against a broad range of pathogens. However, high sequence divergences makes it FURTHER READING difficult to identify genes in a new species by a targeted approach Seppola M, Stenvik J, Solstad T, Steiro K, Robertsen homology cloning ; , and gene discovery by screening methods is B and Jensen I 2006. Sequence and expression analysis of an thus more efficient. The use of techniques like suppression interferon stimulated gene ISG15 ; from Atlantic cod Gadus subtractive hybridization SSH ; makes it feasible to extract morhua L ; . Developmental & Comparative Immunology, expressed genes ESTs ; that are up-regulated by a particular in press. n stimulus. We have thus generated an EST library with the use of polyinosinic polycytidylic acid poly I: C ; which is known to have strong immune stimulatory FIGURE 3: RELATIVE GENE EXPRESSION OF ATLANTIC COD ISG15 FOLLOWING INJECTION WITH V ANGUILLARUM properties, mimicking a viral infection. We have sequenced about 1000 ESTs and analyzed them by comparison against sequences in the GenBank. These analyses revealed that approximately seven percent of the ESTs were immune related, 41 percent represented other genes, while 52 percent had no apparent similarity to known genes from other species. Some of the immune related genes were used for further applications and development of quantitative gene expression assays.
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MYCOBACTERIUM TUBERCULOSIS: An In-depth Discussion for Embalmers Part 2 By: James H. Bedino, Chemist Dir. Research The Champion Company.
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41. The Delegation of South Africa considered that the harmonization of trademark law was a truly important aspect. However, countries were at different levels of development and therefore the Delegation would prefer that a development-impact assessment be conducted in this regard, so that members could be assured that there was truly a development benefit to be derived from the harmonization of substantive trademark law. 42. The Delegation of Japan supported the idea to initiate work on the harmonization of substantive trademark law. The Delegation noted that, with economic globalization, businesses from all over the world were required to survive fierce international competition and itwas important for companies to carry out their economic activities more quickly. Under those circumstances, the trademark system should be designed to satisfy the needs of companies and businesses. Specifically, it should be designed in a way that the users could more easily prepare and file applications and more accurately assess the registrability of the trademarks they applied for. In order to do so, harmonization of the trademark system was essential on substantive as well as on procedural and formality aspects. The issue of harmonization of trademark procedures and formalities was already taken up in the framework of the Madrid Agreement and Protocol and in the Trademark Law Treaty. Therefore, the Delegation considered that the SCT should engage in the substantive harmonization of trademark law. The Delegation considered that, before starting the discussion on this issue, from a point of view of efficiency, Members of the SCT should first analyze the summary of the replies to the Questionnaire on Trademark Law and Practice, in order to clarify the similarities and differences in the trademark systems of Member States. Through this process, the Committee could identify items in which priority should be set or in which harmonization could be easily achieved. The Delegation believed that the questionnaire could provide valuable information to be considered in the future and declared its particular interest in the harmonization of possible grounds for refusal and in the area of the post-grant opposition systems. 43. The Chair noted that the Delegation of Japan had not submitted proposals for the future work of the SCT, prior to the current session. However, the proposals it had just submitted to the Standing Committee should also be discussed by Members. 44. The Delegation of Iran Islamic Republic of ; , speaking on behalf of the Group of Countries of Asia and the Pacific, declared that even though the group had expressed concerns about the harmonization of substantive trademark law, it could support the idea of conducting studies on the implications of specific areas of harmonization for developing countries. 45. The Delegation of Kenya said that probably the concept of substantive law needed to be construed in relation to the principle of territoriality, which was basic in trademark law. The term substantive would need to be clarified if used in relation to harmonization, because the breath of both concepts together could be too far reaching. Explaining these concepts would help all delegations to understand what was at stake in this exercise, regardless of their level of development. 46. The Delegation of New Zealand held the view that the broad topic of harmonization of substantive trademark law should be given a lower priority in the future work program of the SCT. The Standing Committee had already devoted a substantial portion of its time over the last few years to trademark issues and in particular the revision the Trademark Law Treaty. Once that work was completed, the SCT could more usefully progress work in other areas of interest.
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Fig. 1. Static X-ray of the head of an anaesthetized Chameleo pardalis with lead markers implanted into the jaws and tongue see Materials and methods ; . At the back of the head, the hyoid apparatus is clearly visible arrow ; . The Lizard tongue has been placed over the 20 mm head of a dead Anolis lizard to illustrate the shape of the tongue and the position of the pouch marker 11 ; just after prey contact. The numbering shows the positions of the markers used to analyse tongue movements see Materials and methods and gleevec.
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P-W-109 COMPARISON OF THROMBIN GENERATION WITH MODIFIED THROMBOELASTOMETRY IN HAEMOPHILIA A J. J. Van Veen * UK ; , A. Gatt, A. E. Bowyer, P. C. Cooper, S. Kitchen, M. Makris ACQUIRED HEMOPHILIA A IN A PATIENT WITH HYDATID DISEASE: A CASE REPORT M. E. Vega-Ostertag * AR ; , L. Surez Gonzales, F. Pagani DETECTION OF LARGE DELETIONS IN HAEMOPHILIA A: CARRIER DETECTION BY MP LC MULTIPLEX PCR LIQUID CHROMATOGRAPHY ; C. Vinciguerra * FR ; , A. Force, D. Pellecchia, M. Fretigny, C. Negrier MRNA ANALYSIS IN A SEVERE HAEMOPHILIA A PATIENT: DETECTION OF AN EXON 6 SKIPPING C. Vinciguerra * FR ; , F. Martel, D. Pellecchia, M. Fretigny, C. Negrier EFFECT OF RFVIIA AND NN1731 RFVIIA ANALOGUE ; ON THROMBOELASTOGRAPHY TEG ; IN WHOLE BLOOD OBTAINED FROM HAEMOPHILIA A DOGS D. Viuff * DK ; , M. Ezban, V. Lind, A. Dillow, R. Raymer, E. Merricks, T. Nichols DATABASE MANAGEMENT SYSTEM FOR A HAEMOPHILIA COMPREHENSIVE CARE CENTRE C. Von Auer * DE ; , W. Rohlfing, I. Scharrer RAPID INCREASE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HAEMOPHILIA AND CHRONIC HCV- INFECTION C. Von Auer * DE ; , S. Heinsdorf, M. Krause, W. Miesbach, I. Scharrer SIGNIFICANT DISTINCTION BETWEEN PLASMA- AND PLATELET-DEPENDENT COAGULATION ACTIVITY IN HEMOPHILIA A PATIENTS U. M. K. Wartiovaara-Kautto * FI ; , S. Ilveskero, L. Joutsi-Korhonen, M. Lemponen, K. Kuukka, E. Armstrong, R. Lassila BLOOD BORNE VIRUS INFECTIONS IN YOUNG HAEMOPHILIACS IN POLAND J. Windyga * PL ; , P. Grabarczyk, A. Klukowska, A. Buczma, P. Laguna, E. Stefanska, A. Szczepanik, M. Mikulska, E. Brojer THE EFFECT OF APCC AND PCC ON THE GENERATION OF THROMBIN IN HAEMOPHILIA A PATIENTS WITH FVIII INHIBITOR: A CROSS-OVER PHARMACOKINETIC STUDY J. Windyga * PL ; , K. Varadi, B. Baran, B. Keil, P. Turecek WHAT DOES HIGH PREVALANCE OF FACTOR V LEIDEN MUTATION IN POLISH SEVERE HAEMOPHILIACS MEAN? J. Windyga * PL ; , A. Buczma, E. Stefanska, K. Bykowska, B. Baran RECURRENCE OF THE FACTOR VIII GENE R531H MUTATION IN 13 IRISH FAMILIES: EVIDENCE FOR A FOUNDER EFFECT P. C. Winter UK ; , H. Egan, O. McNulty, F. Jones, J. O'Donnell, V. Jenkins * THE EFFECT OF TEST CONDITIONS ON THROMBOELASTOGRAPHY PARAMETERS IN HEMOPHILIACS WITH AND WITHOUT INHIBITORS G. Young * US ; , D. Yassin, D. J. Nugent EFFECTIVE TREATMENT OF INTRACRANIAL HEMORRHAGE IN A SEVERE HEMOPHILIA B PATIENT E. Zanon * IT ; , M. Sartori, G. Saggiorato, R. Mardari, R. Manara, G. Cella and glucagon.
ACKNOWLEDGMENTS The authors thank Jian-Hua Liu for excellent technical assistance. This work was supported by National Institutes of Health grants: NIDDK-KO1-060580 to V.R.A., RR02512 to M.E.H., and P01-HL64190 to K.A.H., and research grants from Hemophilia of Georgia and The Howard Hughes Medical Institutes and gentamicin.
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M, Chikaoka H, Sasano N. Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy. Cancer 1985; 55: 28452849. Matsuoka S, Itoh M, Shinonome T, Tanimura A. Intramedullary spinal cord germinoma: case report. Surg Neurol 1991; 35: 122126. Nagasawa S, Kikuchi H, Yamashita J, Mitsuno K. Intracranial and spinal germinomas occurring four years after spinal cord germinoma: case report. Neurol Med Chir Tokyo ; 1991; 31: 729 Hanafusa K, Shibuya H, Abe M, Yamaura K, Suzuki S. Intramedullary spinal cord germinoma: case report and review of the literature. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1993; 159: 203204. Slagel DD, Goeken JA, Platz CA, Moore SA. Primary germinoma of the spinal cord: a case report with 28-year follow-up and review of the literature. Acta Neuropathol 1995; 90: 657 Matsuyama Y, Nagasaka T, Mimatsu K, Inoue K, Mii K, Iwata H. Intramedullary spinal cord germinoma. Spine 1995; 20: 2338 Itoh Y, Mineura K, Sasajima H, Kowada M. Intramedullary spinal cord germinoma: case report and review of the literature. Neurosurgery 1996; 38: 187191. Miyauchi A, Matsumoto K, Kohmura E, Doi T, Hashimoto K, Kawano K. Primary intramedullary spinal cord germinoma: case report. J Neurosurg 1996; 84: 1060 Baleriaux D, Parizel P, Bank WO. Intraspinal and intramedullary pathology. In and glucosamine!
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