Carboplatin dosing equation
References : 1- P.M. St. John et al., Diffraction-Based Cell Detection Using a Microcontact Printed antibody Grating, Anal. Chem., 70, 1108-1111, 1998 C. Thibault, C. Severac, E. Trvisiol and C. Vieu, Microtransfer molding of hydrophobic dendrimer , Microelectronic Engineering 83, 1513-1516, 2006 Esfand, R.; Tomalia, Poly amidoamine ; PAMAM ; dendrimers: from biomimicry to drug delivery and biomedical applications, D. A. D. D. T., 6, 427, 2001.
Jonathan S. Berek, M.D. A Study of Different Chemotherapy Treatments for Women with Ovarian or Peritoneal Cancer GOG #182 UCLA IRB #01-01-062 Ovarian Cancer or Peritoneal Cancer Paclitaxel and Carboplatin and the drugs most commonly used to treat ovarian and peritoneal cancer. Three new drugs appear promising for the treatment of these diseases. These drugs are topotecan, gemcitabine, and liposomal doxorubicin Doxil ; . Topotecan has been approved by the Food and Drug Administration FDA ; for the treatment of ovarian cancer but gemcitabine and doxil have not. This particular study will test different ways of combining each of these drugs with one of the standard treatment programs. The doses and schedules for each combination have been adjusted to have similar side effects and overall duration of treatment. This study will look at the side effects of each combination and how well each treatment combination works against ovarian cancer. The possible treatments are.
SEVERE SEPSIS AS CAUSE OF CLINICAL FAILURE IN COMMUNITY ACQUIRED PNEUMONIA Fidaa Shaib MD * Maria Cirino-Marcano MD Paula Peyrani Dicastelnuov MD Julio Ramirez MD University of Louisville, Louisville, KY PURPOSE: To determine the incidence, timing, and clinical outcomes of patients with community acqiured pneumonia who develop severe sepsis. METHODS: This was a retrospective review of records of 528 patients admitted with community acqiured pneumonia CAP ; at the University of Louisville Hospital and the Veterans Affairs Medical Center of Louisville between 1997 and 2000. Patients who received appropriate antimicrobial treatment and met criteria for clinical failure and severe sepsis were included.
For CHVP, n 80; for HDT, n 86. CHVP indicates cyclophosphamide, doxorubicin, etoposide, prednisone; HDT, high-dose therapy; and FLIPI, Follicular Lymphoma Prognostic Index.
Serono, are not of high quality and permit no firm conclusions to be drawn regarding the outcomes of such treatment. In these circumstances the company cannot understand the basis upon which the Appraisal Committee was able to assess the relative clinical and cost effectiveness of carboplatin as compared to cetuximab, without which no conclusions regarding its usage may properly be drawn.
Abortus fever 023.9 Aboulomania 301.6 Abrachia 755.20 Abrachiatism 755.20 Abrachiocephalia 759.89 Abrachiocephalus 759.89 Abrami's disease acquired hemolytic jaundice ; 283.9 Abramov-Fiedler myocarditis acute isolated myocarditis ; 422.91 Abrasion - see also Injury, superficial, by site cornea 918.1 dental 521.2 teeth, tooth dentifrice ; habitual ; hard tissues ; occupational ; ritual ; traditional ; wedge defect ; 521.2 Abrikossov's tumor M9580 0 ; - see also Neoplasm, connective tissue, benign malignant M9580 3 ; - see Neoplasm, connective tissue, malignant Abrism 988.8 Abruption, placenta - see Placenta, abruptio Abruptio placentae - see Placenta, abruptio Abscess acute ; chronic ; infectional ; lymphangitic ; metastatic ; multiple ; pyogenic ; septic ; with lymphangitis ; see also Cellulitis ; 682.9 abdomen, abdominal cavity - see Abscess, peritoneum wall 682.2 abdominopelvic - see Abscess, peritoneum accessory sinus chronic ; see also Sinusitis ; 473.9 adrenal capsule ; gland ; 255.8 alveolar 522.5 with sinus 522.7 amebic 006.3 bladder 006.8 brain with liver or lung abscess ; 006.5 liver without mention of brain or lung abscess ; 006.3 with brain abscess and lung abscess ; 006.5 lung abscess 006.4 lung with liver abscess ; 006.4 with brain abscess 006.5 seminal vesicle 006.8 specified site NEC 006.8 spleen 006.8 anaerobic 040.0 ankle 682.6 anorectal 566 antecubital space 682.3 antrum chronic ; Highmore ; see also Sinusitis, maxillary ; 473.0 anus 566 apical tooth ; 522.5 with sinus alveolar ; 522.7 appendix 540.1 areola acute ; chronic ; nonpuerperal ; 611.0 puerperal, postpartum 675.1 arm any part, above wrist ; 682.3 artery wall ; 447.2 atheromatous 447.2 auditory canal external ; 380.10 auricle ear ; staphylococcal ; streptococcal ; 380.10 and carmustine.
Abraxane and carboplatin in breast cancer
The following key factors should be taken into consideration when compiling learning materials for non-formal education: 150 1. Meeting the actual learning needs of local people for economic development according to the practical reality in rural areas 2. Ensuring learner participation in the entire process of materials development 3. Including income-generating programmes in the curricula for nonformal education 4. Integrating learning harmoniously into the social development of each rural community.
1590 patient underwent two further chemotherapy cycles with cisplatin and etoposide. From April to August 2000, the marker values remained within normality, but unfortunately in September 2000 two subsequent measurements of AFP were 196 ng ml and 406 ng ml, respectively. A CT scan of the chest and abdomen, PET positron emission tomography ; scan and brain MRI magnetic resonance imaging ; scan did not reveal disease recurrence. On October 2000, AFP rose to 1600 ng ml. We decided on a third-line chemotherapy consisting of docetaxel 40 mg m2 administered intravenously on days 1, 8, 15 and 21 of each 28-day cycle. The AFP serum levels monitored every week showed a progressive decrease, attaining normality 11 ng ml ; after 2 months. The CT scan performed after four cycles still documented no evidence of disease. In February 2003, the patient was disease free and the AFP value was 3.8 ng ml. The treatment of patients with primary MNSGCT, refractory to cisplatin-based chemotherapy, who relapse after salvage surgery, is challenging. No known treatment appears to cure or substantially prolong survival [1]. High-dose therapy with carboplatin and etoposide was excluded in this patient since it would have subjected him to severe toxicity with at best a very brief response. Single agent paclitaxel [2, 3] or the combination of paclitaxel and gemcitabine [4] have been found to be active as a third-line approach in patients with germ-cell tumors, but long lasting complete response were rarely observed. To our knowledge, the activity of docetaxel has never been tested in this clinical setting. The 26 months disease free survival obtained with docetaxel in a weekly schedule is therefore noteworthy and makes this case unique. This man has a chance of a cure, since relapse is rare in germ-cell tumor patients who achieve a complete response for 2 years [5]. A. Berruti1, A. Saini1, G. Gorzegno1, M. Tampellini1, P. Borasio2 & L. Dogliotti1 and carteolol.
Activities on day 8 ; , with a concomitant and significant increase of urinary creatmine. At the end of the carboplatin infusion, the urinary creatinine concentrations returned to basal values, but the GGT and NAG activities remained significantly increased. Six patients showed low myelotoxicity grade 1-2 four others showed severe myelotoxicity grade 3-4 ; , followed by a low and temporary increase of serum creatinine 1 week after the end of therapy. The most severe increases of tubular enzymes, concomitant to the clinical toxicity, were always observed in patients who had previously undergone cisplatin.
Carboplatin and paclitaxel side effects
How much pemetrexed can be administered with radiation therapy in a group of patients who would receive palliative radiation therapy alone; in those patients, it would be justified to use something other than standard concurrent chemoradiation therapy. In that patient population, pemetrexed can be administered at full doses with radiation therapy. Currently, we are adding carboplatin to that regimen and caverject.
Corresponding author: Dr. Murli Manohar University of Illinois College of Veterinary Medicine 212 Large Animal Clinic 1102 W. Hazelwood Drive Urbana, IL 61802 USA Tel.: 217-333-1940 Fax: 217-244-1652 E-mail address: mmanohar uiuc.
187. Doz F, Pinkerton R. What is the place of carboplatin in the paediatric oncology? Eur J Cancer. 1994; 30A: 194 and cefazolin.
Arthur B. Modell The Hon. Diana G. Motz * William H. Munn * ex officio Morris W. Offit * Walter D. Pinkard Jr. Christian H. Poindexter Arnold I. Richman Francis G. Riggs Theo C. Rodgers * Alton J. Scavo * Mayo A. Shattuck III Huntington Sheldon, M.D. * Donald J. Shepard * Thomas G. Snead Jr. Louis B. Thalheimer * Beverly J. White-Seals, Esq. ex officio Emeritus Trustees Andre W. Brewster, Esq. A. James Clark Leslie B. Disharoon Manuel Dupkin II Robert D.H. Harvey Alan P. Hoblitzell Jr. Robert E. Mason, M.D. William J. McCarthy, Esq. Harvey M. Meyerhoff Milton H. Miller Frederick O. Mitchell Anne M. Pinkard Henry A. Rosenberg Richard S. Ross, M.D. B. Francis Saul II R. Champlin Sheridan Wendell A. Smith, Esq. Calman J. Zamoiski.
WARNING Carboplatin injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available. Bone marrow suppression is dose related and may be severe, resulting in infection and or bleeding. Anemia may be cumulative and may require transfusion support. Vomiting is another frequent drug-related side effect. Anaphylactic-like reactions to carboplatin have been reported and may occur within minutes of carboplatin administration. Epinephrine, corticosteroids, and antihistamines have been employed to alleviate symptoms. DESCRIPTION Carboplatin injection is supplied as a sterile, pyrogen-free, 10 mg mL aqueous solution of carboplatin. Carboplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. The chemical name for carboplatin is platinum, diammine [1, 1-cyclobutane-dicarboxylato 2- ; -0, 0']-, SP-4-2 ; , and has the following structural formula and cefprozil.
The GH levels of the two subjects profiled over 12 h demonstrate a peak at 4 h, followed by a gradual decline to baseline by 12 h, as reported by Jorgensen et al. 18 ; in children. GH levels remained in the high physiological range in both subjectsfor only approximately 6 h of 24-h day. Discussion We have studied the effects of relatively low doses of rhGH on carbohydrate metabolism and insulin secretion in 10 GH-deficient adults over a 3-month period. IGF-I was raised to within the physiological range by rhGH therapy throughout the study period. However, glucose tolerance Kg ; and insulin sensitivity Si ; decreasedat 1 week with an.
Carboplatin area under the curve calculator
Figure 4. In vivo Activity of PXD101 Monotherapy and Combination Therapy with Carboplatin on Human Ovarian Cancer Xenografts and ceftriaxone.
Authors in regard to the emotional and psychological problems created for children by divorce and ways of helping parents to deal with the situation "realistically and reassuringly." As would be expected in such a compilation, there is considerable duplication in content with occasional slight differences of opinion. One misses the contribution of a social worker, since many problems of divorce reach family and child welfare agencies so frequently. This is a good guide for persons directly or indirectly involved in helping children of divorced parents and in suggesting ways divorced parents can prepare their children for the final decision ELIZABETH P. RICE to divorce and carboplatin.
Berenson R, Crowley JJ, Grogan TM, Zangari M, Briggs AD, Mills GM, Barlogie B, Salmon SE. Maintenance therapy with alternate-day prednisone improves survival in multiple myeloma patients. Blood 99 9 ; : 3163-3168, 2002. Ramsey SD, Moinpour CM, Lovato LC, Crowley JJ, Grevstad P, Presant CA, Rivkin SE, Kelly K, and Gandara DR. Economic analysis of vinorelbine plus cisplatin versus paclitaxel plus carboplatin for advanced non-small-cell lung cancer. J Natl Cancer Inst 94 4 ; : 291-297, 2002. Albain K, Crowley JJ, Turrisi III AT, Gandara DR, Farrar WB, Clark JI, Beasley KR, Livingston RB. Concurrent cisplatin, etoposide, and chest radiotherapy in pathologic stage IIIB Non-smallcell lung cancer: A Southwest Oncology Group Phase II Study, SWOG 9019. Journal of Clinical Oncology 20 16 ; : 3454-3460, 2002. LeBlanc M, Jacobson J, Crowley J. Partitioning and peeling for constructing prognostic groups. Stat Methods Med Res 11: 247-274, 2002. Pauler DK, Gower KB, Goodman PJ, Crowley JJ, Thompson IM. Biomarker-based methods for determining noncompliance in a prevention trial. Control Clin Trials 23: 675-685, 2002. Gandara DR, Chansky K, Albain KS, Leigh BR, Gaspar LE, Lara PN Jr, Burris H, Gumerlock P, Kuebler JP, Bearden JD, Crowley J, Livingston R. Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group study S9504. Journal of Clinical Oncology 21 10 ; : 2004-2010, 2003. Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA Jr. The influence of finasteride on the development of prostate cancer. N Engl J Med 349 3 ; : 215224, 2003. Jacobson JL, Hussein MA, Barlogie B, Durie BGM, Crowley J. A new staging system for multiple myeloma patients based on the Southwest Oncology Group SWOG ; experience. British Journal of Haematology 122: 441-450, 2003. Jacobson J, Barlogie B, Shaughnessy J, Drach J, Tricot G, Fassas A, Zangari M, Giroux DJ, Crowley J, Hough A, Sawyer J. MDS-type abnormalities within myeloma signature karyotype MM-MDS ; : only 13% 1-year survival despite tandem transplants. British Journal of Haematology 122: 430-440, 2003. Dhodapkar MV, Jacobson JL, Gertz MA, Crowley JJ, Barlogie B. Prognostic Factors and Response to Fludarabine Therapy in Waldenstrom's Macroglobulinemia: an update of the US Intergroup trial SWOG S9003 ; . Seminars in Oncology 30 2 ; : 220-225, 2003. Unger JM, LeBlanc M, Crowley JJ, Grossman B, Natale RB, Wozniak AJ, Berenson JR, List AF, Peters WA III, Flanigan RC, Macdonald JS, Al-Sarraf M, Thompson IM, and Coltman CA Jr. Estimating the impact of new clinical trial proven cancer therapy and cancer chemoprevention on population mortality: The Karnofsky memorial lecture. Journal of Clinical Oncology 21 ; 23: 246252, 2003. Edelman MJ, Chansky K, Gaspar LE, Leigh B, Weiss GR, Taylor SA, Crowley J, Livingston R, Gandara DR. Phase II trial of cisplatin etoposide and concurrent radiotherapy followed by paclitaxel carboplatin consolidation for limited small-cell lung cancer: Southwest Oncology Group 9713. Journal of Clinical Oncology 22 1 ; : 127- 132, 2004. Tangen C, Goodman P, Crowley J and Thompson I. Statistical design issues and other practical considerations for conducting phase III prostate cancer prevention trials. J Urol 171: S64-S67, 2004. Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, Minasian LM, Ford LG, Lippman SM, Crawford ED, Crowley JJ and Coltman Jr. CA. Prevalence of prostate cancer among men with prostate-specific antigen level 4.0 ng per milliliter. N Engl J Med 350 22 ; : 2239-2246, 2004. Durie BGM, Jacobson J, Barlogie B and Crowley J. Magnitude of response with myeloma frontline therapy does not predict outcome: Importance of time to progression in Southwest Oncology Group Chemotherapy Trials. Journal of Clinical Oncology 22 10 ; : 1857-1863, 2004 and celestone.
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Accumulated cells in the S phase, the most sensitive to gemcitabine, and a positive correlation was found between the expression ratio of dCK: RR and gemcitabine sensitivity. Indeed, pemetrexed significantly enhanced dCK gene expression in MIA PaCa-2, PANC-1, and Capan-1 cells, and the crucial role of this enzyme was confirmed by impairment of gemcitabine cytotoxicity after dCK inhibition with 29-deoxycytidine, thus demonstrating that gemcitabine and pemetrexed combination displays schedule-dependent synergistic cytotoxic activity, favorably modulates cell cycle, induces apoptosis, and enhances dCK expression in pancreatic cancer cells [7]. The same combination was tested against A549, Calu-1, and Calu-6 NSCLC cells. Synergistic cytotoxicity was demonstrated, and pemetrexed significantly decreased the amount of phosphorylated Akt, enhanced apoptosis, and upregulated dCK in A549 and Calu-6 cells, as well as hENT1 in all cell lines. Gemcitabine sensitivity was related to dCK expression, whereas transcription levels of TS, DHFR, and GARFT, the cellular targets of pemetrexed Figure 1 ; , were predictive of drug chemosensitivity, being higher in resistant cells. These results suggest that gemcitabine and pemetrexed synergistically interact against NSCLC cells through modulation of nucleotide pools, suppression of Akt phosphorylation and induction of apoptosis and pemetrexed enhances dCK and hENT1 expression, thus underlying the role of gene-expression modulation for rational development of chemotherapy combinations [9]. The isobologram analysis of cells treated with rapamycin in vitro alone and in combination with various anticancer drugs, showed synergistic interactions in combinations with paclitaxel, carboplatin, and vinorelbine. Additive effects were observed in combinations with doxorubicin and gemcitabine. Rapamycin dramatically enhanced paclitaxel- and carboplatin-induced apoptosis. This effect was sequence-dependent and mediated, at least in part, through caspase activation. Furthermore, rapamycin enhanced chemosensitivity to paclitaxel and carboplatin in HER2 neu-overexpressing cells [11]. Gemcitabine and paclitaxel dose-dependently inhibited the proliferation of bladder cancer cell lines and the combination yielded schedule-dependent cytotoxicity since the simultaneous treatment with gemcitabine paclitaxel was associated with superior cytotoxicity after 48 h and 72 h, while sequential treatment showed similar results when gemcitabine was given.
Table 4. Comparison of Na -dependent active urea transport mechanisms in IMCD subsegments and cellcept.
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